Evidence map›Paper›PMID 35251630›Full record

ArticleMolecular and clinical oncology2022

Nivolumab-induced lichenoid granulomatous stomatitis in a patient with advanced melanoma: A case report.

P Gouveris, E A Georgakopoulou, A Grigoraki, D N Zouki, V E Kardara, S Ioannou, D Tryfonopoulos, S Demiri, I Gkouveris

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Molecular and clinical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

P GouverisSecond Department of Medical Oncology, Agios Savvas Cancer Hospital, 11522 Athens, Greece.
E A GeorgakopoulouLaboratory of Histology-Embryology Molecular Carcinogenesis Group, National and Kapodistrian University of Athens, 11527 Athens, Greece.
A GrigorakiDepartment of Pathology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
D N ZoukiSecond Department of Medical Oncology, Agios Savvas Cancer Hospital, 11522 Athens, Greece.
V E KardaraSecond Department of Medical Oncology, Agios Savvas Cancer Hospital, 11522 Athens, Greece.
S IoannouSecond Department of Medical Oncology, Agios Savvas Cancer Hospital, 11522 Athens, Greece.
D TryfonopoulosSecond Department of Medical Oncology, Agios Savvas Cancer Hospital, 11522 Athens, Greece.
S DemiriSecond Department of Medical Oncology, Agios Savvas Cancer Hospital, 11522 Athens, Greece.
I GkouverisDepartment of Oral and Maxillofacial Pathology and Medicine, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece.
St Savas Hospital · GRNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lichenoid granulomatous reactions (LGR) are granulomatous inflammations of the skin and oral mucosa, also sharing features of lichenoid lesions. Thus, the present study refers to lichenoid granulomatous dermatitis (LGD) and lichenoid granulomatous stomatitis (LGS). LGR is a condition that can be triggered by drugs, diseases or environmental causes. In the present case study, anti-PD1 (nivolumab) medication had a detrimental effect on the oral mucosa, which clinicaly and histologicaly proved to be LGS. Checkpoint inhibitors consitute a cornerstone in the current treatment of several types of cancer, of which cutaneous melanoma is the best example. Oral lichenoid responses following anti-PD-1 therapy have been recorded in few case reports and small case series. To the best of our knowledhe, this is the first case of LGS being reported as a side effect of immune checkpoint inhibitor treatment.

Indexed as

immune-related adverse eventslichenoid granulomatous stomatitismelanomanivolumab

Identifiers

PMID35251630
PMCPMC8892467
OpenAlexW4210908155

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.