Evidence map›Paper›PMID 35251554›Full record

ArticleJournal of nanostructure in chemistry2023

Polymeric nanoparticles and nanomicelles of hydroxychloroquine co-loaded with azithromycin potentiate anti-SARS-CoV-2 effect.

Aline Oliveira da Siliva de Barros, Suyene Rocha Pinto, Sara Rhaissa Rezende Dos Reis, Eduardo Ricci-Junior, Luciana Magalhães Rebelo Alencar, Nancy Cristina Junqueira Bellei, Luiz Ramos Mário Janini, Juliana Terzi Maricato, Daniela Santoro Rosa, Ralph Santos-Oliveira

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nanostructure in chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Aline Oliveira da Siliva de BarrosLaboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Nuclear Engineering Institute, Brazilian Nuclear Energy Commission, Rio de Janeiro, Brazil.
Suyene Rocha PintoLaboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Nuclear Engineering Institute, Brazilian Nuclear Energy Commission, Rio de Janeiro, Brazil.
Sara Rhaissa Rezende Dos ReisLaboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Nuclear Engineering Institute, Brazilian Nuclear Energy Commission, Rio de Janeiro, Brazil.
Eduardo Ricci-JuniorGalenical Development Laboratory, College of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Luciana Magalhães Rebelo AlencarDepartment of Physics, Federal University of Maranhão, Maranhão, Brazil.
Nancy Cristina Junqueira BelleiDepartment of Medicine, Federal University of São Paulo, São Paulo, Brazil.
Luiz Ramos Mário JaniniDepartment of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, Brazil.
Juliana Terzi MaricatoDepartment of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, Brazil.
Daniela Santoro RosaDepartment of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, Brazil.
Ralph Santos-OliveiraLaboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Nuclear Engineering Institute, Brazilian Nuclear Energy Commission, Rio de Janeiro, Brazil.ORCID 0000-0002-7221-6404
Universidade Federal de São Paulo · BRNuclear Engineering Institute · BRUniversidade Estadual da Zona Oeste · BRUniversidade Federal do Maranhão · BRUniversidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The outbreak of coronavirus (COVID-19) has put the world in an unprecedented scenario. To reestablish the world routine as promote the effective treatment of this disease, the world is looking for new (and old) drug that can efficiently kill the virus. In this study, we have developed two nanosystems: polymeric nanoparticles and nanomicelles-based on hydroxychloroquine and azithromycin. The nanosystem was fully characterized by AFM and DLS techniques. Also, the nanosystems were radiolabeled with Graphical abstract: Supplementary Information: The online version contains supplementary material available at 10.1007/s40097-022-00476-3.

Indexed as

COVID-19DrugNanotechnologySARS-CoV-2TreatmentVirus

Identifiers

PMID35251554
PMCPMC8881703
OpenAlexW4214608205

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.