Evidence map›Paper›PMID 35251309›Full record

ArticleTherapeutic advances in neurological disorders2022

Direct to angiography suite approaches for the triage of suspected acute stroke patients: a systematic review and meta-analysis.

Alex Brehm, Ioannis Tsogkas, Johanna M Ospel, Christian Appenzeller-Herzog, Junya Aoki, Kazumi Kimura, Johannes A R Pfaff, Markus A Möhlenbruch, Manuel Requena, Marc J Ribo and 4 more

Open access · goldAbstract read
In one paragraph

Article in Therapeutic advances in neurological disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Efficacy and safety of bridging intravenous thrombolysis before mechanical thrombectomy in acute ischemic stroke: A systematic review and meta-analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  4. Direct to hybrid CT-angiosuite (Nexaris) reduces treatment time for stroke thrombectomy (Direct-ST): A prospective simulation study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 6 countries.

Alex BrehmDepartment of Neuroradiology, Clinic of Radiology and Nuclear Medicine, University Hospital Basel, 4031 Basel, Switzerland.ORCID https://orcid.org/0000-0002-1630-6210
Ioannis TsogkasDepartment of Neuroradiology, Clinic of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland.
Johanna M OspelDepartment of Neuroradiology, Clinic of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland.
Christian Appenzeller-HerzogUniversity Medical Library Basel, University Basel, Basel, Switzerland.
Junya AokiDepartment of Neurology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Kazumi KimuraDepartment of Neurology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Johannes A R PfaffDepartment of Neuroradiology, Christian Doppler Medical Center, Paracelsus Medical University, Salzburg, Austria.
Markus A MöhlenbruchDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Manuel RequenaDepartment of Neurology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.ORCID https://orcid.org/0000-0002-5671-6484
Marc J RiboDepartment of Neurology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Amrou SarrajDepartment of Neurology, University of Texas McGovern Medical School, Houston, TX, USA.
Alejandro M SpiottaDepartment of Neurosurgery, Medical University of South Carolina, Charleston, SC, USA.
Peter SpornsDepartment of Neuroradiology, Clinic of Radiology and Nuclear Medicine, University Hospital Basel, Basel, SwitzerlandDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0002-3028-0539
Marios-Nikos PsychogiosDepartment of Neuroradiology, Clinic of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland.
University Hospital of Basel · CHNippon Medical School · JPVall d'Hebron Hospital Universitari · ESHeidelberg University · DEMedical University of South Carolina · USParacelsus Medical University · ATThe University of Texas Health Science Center at Houston · USUniversität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreasing evidence suggests improved time metrics leading to better clinical outcomes when stroke patients with suspected large vessel occlusion (LVO) are transferred directly to the angiography suite (DTAS) compared with cross-sectional imaging followed by transfer to the angiography suite. We performed a systematic review and meta-analysis on the efficacy and safety of DTAS approaches.

methodsWe searched Embase, Medline, Scopus, and clinicaltrials.gov for studies comparing outcomes of DTAS and conventional triage. Eligible studies were assessed for risk of bias. We performed a random-effects meta-analysis on the differences of median door-to-groin and door-to-reperfusion times between intervention and control group. Secondary outcomes included good outcome at 90 days (modified Rankin Scale ⩽ 2) rate of symptomatic intracranial hemorrhage (sICH) and mortality within 90 days.

resultsEight studies (one randomized, one cluster-randomized trial and six observational studies) with 1938 patients were included. Door-to-groin and door-to-reperfusion times in the intervention group were on median 29.0 min [95% confidence interval (CI): 14.3-43.6;

conclusionDTAS approaches for the triage of suspected LVO patients led to a significant reduction in door-to-groin and door-to-reperfusion times but an effect on functional outcome was not detected. The subgroup analysis showed similar results for transfer and mothership patients.

Indexed as

cone beam CTdirect to angiography approachesmechanical thrombectomystroketriage

Identifiers

PMID35251309
PMCPMC8894963
OpenAlexW4214826638

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.