Evidence map›Paper›PMID 35251293›Full record

ArticleNano today2022

Metformin Bicarbonate-Mediated Efficient RNAi for Precise Targeting of

Jiangsheng Xu, Yunhua Liu, Sheng Liu, Wenquan Ou, Alisa White, Samantha Stewart, Katherine H R Tkaczuk, Lee M Ellis, Jun Wan, Xiongbin Lu and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano today, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Jiangsheng XuFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Yunhua LiuDepartment of Pathology & Pathophysiology, and Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Sheng LiuMelvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Wenquan OuFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Alisa WhiteFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Samantha StewartFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Katherine H R TkaczukMarlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, MD 21201, USA.
Lee M EllisDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Jun WanMelvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Xiongbin LuDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Xiaoming HeFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
University of Maryland, College Park · USIndiana University Health · USIndiana University – Purdue University Indianapolis · USIndiana University School of MedicineMinistry of Education of the People's Republic of China · CNThe University of Texas MD Anderson Cancer Center · USUniversity of Maryland, Baltimore · US

Funding

Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Monica Rosas Lemus · 2017 to 2026
$24.9M
Nanotechnology enabled targeting of p53 deficiency in human cancerR01CA206366 · NCI · UNIV OF MARYLAND, COLLEGE PARK · PI HE, XIAOMING, LU, XIONGBIN · 2016 to 2020
$1.9M
NCI NIH HHS R01 CA206366NIGMS NIH HHS P20 GM121176
6 · The paper itself

Abstract

Colon and rectal cancers are the leading causes of cancer-related deaths in the United States and effective targeted therapies are in need for treating them. Our genomic analyses show hemizygous deletion of

Indexed as

endosomal escapegene deliverymetforminPOLR2Atargeted therapy

Identifiers

PMID35251293
PMCPMC8896823
OpenAlexW4212844992

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.