Evidence map›Paper›PMID 35251049›Full record

ArticleFrontiers in immunology2022

Increased Interleukin 18-Dependent Immune Responses Are Associated With Myopericarditis After COVID-19 mRNA Vaccination.

Taejoon Won, Nisha Aggarwal Gilotra, Megan Kay Wood, David Matthew Hughes, Monica Vladut Talor, Jana Lovell, Aaron Michael Milstone, Charles Steenbergen, Daniela Čiháková

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
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  8. A20 as a Potential Therapeutic Target for COVID-19.Immunity, inflammation and disease · 2025
    Review
  9. An overview of HLA variants in COVID-19 vaccine-induced autoimmunity.International journal of molecular epidemiology and genetics · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Taejoon WonDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Nisha Aggarwal GilotraDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Megan Kay WoodW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States.
David Matthew HughesDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, United States.
Monica Vladut TalorDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Jana LovellDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Aaron Michael MilstoneDivision of Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Charles SteenbergenDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Daniela ČihákováDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Myeloid Cells are Critical in Inflammatory Heart DiseaseR01HL118183 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CIHAKOVA, DANIELA · 2014 to 2023
$4.4M
Role of Sca-1+Cardiac Fibroblasts in Inflammatory Heart Disease`R01HL136586 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CIHAKOVA, DANIELA · 2018 to 2021
$1.6M
The Role of Checkpoint inhibitors in CIAF31AR077406 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI WOOD, MEGAN KAY · 2020 to 2022
$96k
The Role of Pericardial Macrophages in Inflammatory Heart DiseaseF31HL149328 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HUGHES, DAVID · 2019 to 2021
$91k
NHLBI NIH HHS F31 HL149328NHLBI NIH HHS R01 HL118183NHLBI NIH HHS R01 HL136586NIAMS NIH HHS F31 AR077406
6 · The paper itself

Abstract

Myocarditis and myopericarditis may occur after COVID-19 vaccination with an incidence of two to twenty cases per 100,000 individuals, but underlying mechanisms related to disease onset and progression remain unclear. Here, we report a case of myopericarditis following the first dose of the mRNA-1273 COVID-19 vaccine in a young man who had a history of mild COVID-19 three months before vaccination. The patient presented with chest pain, elevated troponin I level, and electrocardiogram abnormality. His endomyocardial biopsy revealed diffuse CD68

Indexed as

2019-nCoV Vaccine mRNA-1273AdultAnimalsCOVID-19HumansImmunityInterleukin-18Killer Cells, NaturalMaleMiceMyocarditisSARS-CoV-2VaccinationYoung Adult2019-nCoV Vaccine mRNA-1273IL18 protein, humanInterleukin-18COVID-19 mRNA vaccineinterleukin 18myopericarditisNK cellsNLRP3 inflammasomeTh1-type immune response

Identifiers

PMID35251049
PMCPMC8894592
OpenAlexW4212935720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.