Evidence map›Paper›PMID 35251032›Full record

ArticleFrontiers in immunology2022

Disrupted Peyer's Patch Microanatomy in COVID-19 Including Germinal Centre Atrophy Independent of Local Virus.

Silvia C Trevelin, Suzanne Pickering, Katrina Todd, Cynthia Bishop, Michael Pitcher, Jose Garrido Mesa, Lucia Montorsi, Filomena Spada, Nedyalko Petrov, Anna Green and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Silvia C TrevelinPeter Gorer Department of Immunology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Suzanne PickeringDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Katrina ToddNational Institute for Health Research (NIHR) Guy's and St. Thomas Biomedical Research Centre at Guy's and St. Thomas NHS Foundation Trust and King's College London, London, United Kingdom.
Cynthia BishopNational Institute for Health Research (NIHR) Guy's and St. Thomas Biomedical Research Centre at Guy's and St. Thomas NHS Foundation Trust and King's College London, London, United Kingdom.
Michael PitcherPeter Gorer Department of Immunology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Jose Garrido MesaNational Institute for Health Research (NIHR) Guy's and St. Thomas Biomedical Research Centre at Guy's and St. Thomas NHS Foundation Trust and King's College London, London, United Kingdom.
Lucia MontorsiPeter Gorer Department of Immunology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Filomena SpadaNational Institute for Health Research (NIHR) Guy's and St. Thomas Biomedical Research Centre at Guy's and St. Thomas NHS Foundation Trust and King's College London, London, United Kingdom.
Nedyalko PetrovNational Institute for Health Research (NIHR) Guy's and St. Thomas Biomedical Research Centre at Guy's and St. Thomas NHS Foundation Trust and King's College London, London, United Kingdom.
Anna GreenDepartment of Histopathology, Guy's and St. Thomas NHS Foundation Trust and King's College London, London, United Kingdom.
Manu Shankar-HariCentre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom.
Stuart J D NeilDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Jo SpencerPeter Gorer Department of Immunology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
King's College London · GBGuy's and St Thomas' NHS Foundation Trust · GBNational Institute for Health Research · GBQueen's Medical Centre · GB

Funding

Medical Research Council MC_PC_15068Medical Research Council MR/V028448/1Wellcome Trust 207442/Z/17/Z
6 · The paper itself

Abstract

Confirmed SARS-coronavirus-2 infection with gastrointestinal symptoms and changes in microbiota associated with coronavirus disease 2019 (COVID-19) severity have been previously reported, but the disease impact on the architecture and cellularity of ileal Peyer's patches (PP) remains unknown. Here we analysed

Indexed as

AtrophyB-LymphocytesCOVID-19Germinal CenterHumansIntestinal MucosaLymphoid TissueMacrophagesPeyer's PatchesSARS-CoV-2T-Lymphocytesatrophy of lymphoid folliclegerminal centregut Sars-Cov2 infectionPeyer’s patchessevere COVID-19

Identifiers

PMID35251032
PMCPMC8893224
OpenAlexW4212947943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.