ArticleFrontiers in endocrinology2022
Pregnancy Outcomes in Thyroid Cancer Survivors: A Propensity Score-Matched Cohort Study.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- The incidence and perinatal outcomes of pregnancy-associated thyroid cancer: an Australian population-based study.Journal of the Endocrine Society · 2026Article
- Thyroid function changes in pregnant women with thyroid cancer and their association with adverse fetal outcomes: a parallel controlled study.BMC pregnancy and childbirth · 2026Article
- Obstetric Complications and Pregnancy Outcomes in Cancer Survivors: A Systematic Review and Meta-Analysis.Cancers · 2025Review
- Advances in reproductive management strategies for thyroid cancer patients during the perinatal period: a narrative review.Frontiers in oncology · 2025Review
- Risk of adverse birth outcomes after adolescent and young adult cancer.JNCI cancer spectrum · 2024Article
- Differentiated thyroid cancer and adverse pregnancy outcomes: a propensity score-matched retrospective cohort study.Frontiers in pediatrics · 2024Article
- Pregnancy outcomes and neonatal thyroid function in women with thyroid cancer: a retrospective study.BMC pregnancy and childbirth · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
backgroundSome female thyroid cancer survivors wish to become pregnant following their cancer treatment. Current studies have shown inconsistent results on pregnancy outcomes in these survivors; however, detailed information on the pathological type, treatment, and gestational thyroid function of these patients are not yet well documented, making the refined assessment of the influence of a history of thyroid cancer and related treatments on pregnancy outcomes challenging.
objectiveTo investigate the risk of adverse pregnancy outcomes in thyroid cancer survivors.
methodsThis was a retrospective cohort study. We included all women aged between 19 and 45 years old who delivered between January 2019 and June 2020 in West China Second University Hospital of Sichuan University. Women with tumors other than thyroid cancer or other thyroid diseases were excluded. The included women were divided into survivors of thyroid cancer (survivors) and women without any history of thyroid disease (controls). Propensity score matching and logistic regression were used to control confounding variables.
resultsAll 18,332 women who met the inclusion criteria were included in the study (96 survivors of papillary thyroid cancer and 18,236 controls). After propensity score matching, 96 survivors and 192 controls were included. The survivors had higher levels of free thyroxine (15.47 [13.61-17.67] vs. 14.38 [13.20-15.81] pmol/mL; P<0.001) and higher levels of thyroid peroxidase antibodies (TPOAb) (43.55 [31.43-71.43] vs. 35.95 [28.00-48.03] U/mL; P=0.008) but similar levels of thyroid stimulating hormone (1.46 [0.56-3.15] vs. 1.36 [0.81-1.92] mIU/mL; P=0.142) than the controls. There were no significant differences in adverse pregnancy outcomes between survivors and controls. Fetal macrosomia was lower among survivors (OR: 0.077, 95% CI: 0.009-0.668. P=0.020) than controls. Additionally, survivors had reduced weight gain during pregnancy (13.0 [10.0-15.0] vs. 14.00 [11.00-16.00] kg, P=0.005) and reduced placental weight (563.0 [514.5-620.0] vs. 572.0 [520.0-650.0] g, P=0.019), albeit with small absolute differences. Thyroidectomy or radioiodine therapy did not adversely affect pregnancy outcomes.
conclusionA history of treated papillary thyroid cancer was not associated with adverse pregnancy outcomes.
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