ArticleFrontiers in endocrinology2022
Trophectoderm Biopsy Differentially Influences the Level of Serum β-Human Chorionic Gonadotropin With Different Embryonic Trophectoderm Scores in Early Pregnancy From 7847 Single-Blastocyst Transfer Cycles.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Diagnostic accuracy of initial serum β-hCG in predicting pregnancy outcomes post-SET in IVF/ICSI cycles: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Evaluation of the clinical utility of poor-quality embryos using an extended in vitro embryo culture system.The Journal of reproduction and development · 2026Article
- Impact of trophectoderm biopsy on serum β-hCG dynamics: PGT cycles vs. non-PGT cycles.Archives of gynecology and obstetrics · 2025Article
- Trophectoderm grade as a predictor of beta human-chorionic gonadotropin rise in early pregnancy.Journal of assisted reproduction and genetics · 2024Article
- Early GnRH-agonist therapy does not negatively impact the endometrial repair process or live birth rate.Frontiers in endocrinology · 2024Article
- Trophectoderm biopsy is associated with adverse obstetric outcomes rather than neonatal outcomes.BMC pregnancy and childbirth · 2023Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate whether trophectoderm (TE) biopsy differentially influence the level of serum β-human chorionic gonadotropin (β-hCG) with different TE-scored blastocysts transferred in early pregnancy.
methodsThis retrospective cohort study contained 7847 single-blastocyst transfer cycles executed between January 2019 and June 2020, including 2657 preimplantation genetic testing (PGT) cycles and 5190
resultsFor cycles with a live birth, in grade A TE score subgroups, the HCG
conclusionsWhile blastocysts with higher TE grades produced higher serum β-hCG levels in early pregnancy, TE biopsy might exert a negative impact on serum β-hCG levels by blastocysts with a grade-B TE score and below. TE biopsy did not increase the risk for adverse obstetric and neonatal outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.