ArticleFrontiers in neurology2022
APOE-ε4 Is Associated With Reduced Verbal Memory Performance and Higher Emotional, Cognitive, and Everyday Executive Function Symptoms Two Months After Mild Traumatic Brain Injury.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Genetic Variants and Persistent Impairment Following Mild Traumatic Brain Injury: A Systematic Review.The Journal of head trauma rehabilitationPooled it
- Genetic factors complicating recovery in patients with brain injury: Possible link between injury severity and posttraumatic neurodegeneration related to intracerebral amyloid deposition - A narrative review.Surgical neurology international · 2026Review
- Association of Alzheimer's Disease Polygenic Risk Score with Concussion Severity and Recovery Metrics.Sports medicine (Auckland, N.Z.) · 2025Article
- APOE4 and age affect the brain entorhinal cortex structure and blood arachidonic acid and docosahexaenoic acid levels after mild TBI.Scientific reports · 2024Article
- Utilization of clinical and radiological parameters to predict cognitive prognosis in patients with mild-to-moderate traumatic brain injury.Frontiers in neuroscience · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSubstantial variance exists in outcomes after mild traumatic brain injury (MTBI), and these differences are not fully explained by injury characteristics or severity. Genetic factors are likely to play a role in this variance.
objectivesThe aim of this study was to examine associations between the apolipoprotein (APOE)-ε4 allele and memory measures at two months post-MTBI and to evaluate whether subjective cognitive and affective symptoms were associated with APOE-ε4 status. Based on previous research, it was hypothesized that APOE-ε4 carriers would show poorer verbal memory performance compared to APOE-ε4 non-carriers.
methodsNeuropsychological data at two months post-injury and blood samples that could be used to assess
resultsThe APOE-ε4 + status was associated with decreased immediate memory recall (
conclusionThe APOE-ε4+ allele has a negative effect on verbal memory and symptom burden two months after MTBI.
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Registered trials
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