Evidence map›Paper›PMID 35250790›Full record

ArticleFrontiers in neurology2021

Brainstem Associated Somatosensory Evoked Potentials and Response to Vagus Nerve Stimulation: An Investigation of the Vagus Afferent Network.

Hrishikesh Suresh, Karim Mithani, Karanbir Brar, Han Yan, Samuel Strantzas, Mike Vandenberk, Roy Sharma, Ivanna Yau, Christina Go, Elizabeth Pang and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Neurostimulation treatments for epilepsy: Deep brain stimulation, responsive neurostimulation and vagus nerve stimulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Hrishikesh SureshInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Karim MithaniInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Karanbir BrarDivision of General Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Han YanProgram in Neuroscience and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Samuel StrantzasDivision of Neurosurgery, Department of Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Mike VandenberkDivision of Neurosurgery, Department of Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Roy SharmaDivision of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
Ivanna YauDivision of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
Christina GoDivision of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
Elizabeth PangProgram in Neuroscience and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Elizabeth KerrDivision of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
Ayako OchiDivision of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
Hiroshi OtsuboDivision of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
Puneet JainDivision of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
Elizabeth DonnerDivision of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
O Carter SneadProgram in Neuroscience and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
George M IbrahimInstitute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
Hospital for Sick Children · CASickKids Foundation · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite decades of clinical usage, selection of patients with drug resistant epilepsy who are most likely to benefit from vagus nerve stimulation (VNS) remains a challenge. The mechanism of action of VNS is dependent upon afferent brainstem circuitry, which comprises a critical component of the Vagus Afferent Network (VagAN). To evaluate the association between brainstem afferent circuitry and seizure response, we retrospectively collected intraoperative data from sub-cortical recordings of somatosensory evoked potentials (SSEP) in 7 children with focal drug resistant epilepsy who had failed epilepsy surgery and subsequently underwent VNS. Using multivariate linear regression, we demonstrate a robust negative association between SSEP amplitude (

Indexed as

epilepsyoutcomessomatosensory evoked potentialsvagus afferent networkvagus nerve stimulation

Identifiers

PMID35250790
PMCPMC8895499
OpenAlexW4212917217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.