Evidence map›Paper›PMID 35250674›Full record

ArticleFrontiers in psychiatry2022

Functional Genomic Analysis of Amphetamine Sensitivity in

Caline S Karam, Brenna L Williams, Irina Morozova, Qiaoping Yuan, Rony Panarsky, Yuchao Zhang, Colin A Hodgkinson, David Goldman, Sergey Kalachikov, Jonathan A Javitch

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. The use ofFrontiers in cell and developmental biology · 2026
    Review
  2. Science signaling · 2025
    Article
  3. The Influence of Cannabinoids onCannabis and cannabinoid research · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Caline S KaramDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United States.
Brenna L WilliamsDivision of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, United States.
Irina MorozovaCenter for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY, United States.
Qiaoping YuanLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, United States.
Rony PanarskyLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, United States.
Yuchao ZhangDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United States.
Colin A HodgkinsonLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, United States.
David GoldmanLaboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, United States.
Sergey KalachikovCenter for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY, United States.
Jonathan A JavitchDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United States.
National Institute on Alcohol Abuse and Alcoholism · USNew York Psychoanalytic Society and Institute · USColumbia University · USNew York Genome Center · USNew York State Psychiatric Institute

Funding

Probing mechanisms of amphetamine action at plasma membrane and vesicular transporters in vitro and in vivoR01DA041510 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JAVITCH, JONATHAN A · 2017 to 2021
$2.7M
Delineating the genetic basis of amphetamine sensitivity using a Drosophila behavioral model Diversity SupplementU01DA042233 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI JAVITCH, JONATHAN A · 2016 to 2020
$2.2M
NIDA NIH HHS R01 DA041510NIDA NIH HHS U01 DA042233
6 · The paper itself

Abstract

Abuse of psychostimulants, including amphetamines (AMPHs), is a major public health problem with profound psychiatric, medical, and psychosocial complications. The actions of these drugs at the dopamine transporter (DAT) play a critical role in their therapeutic efficacy as well as their liability for abuse and dependence. To date, however, the mechanisms that mediate these actions are not well-understood, and therapeutic interventions for AMPH abuse have been limited. Drug exposure can induce broad changes in gene expression that can contribute to neuroplasticity and effect long-lasting changes in neuronal function. Identifying genes and gene pathways perturbed by drug exposure is essential to our understanding of the molecular basis of drug addiction. In this study, we used

Indexed as

amphetamineDGRPdopamine transporterDrosophilamammalian target of rapamycin (mTOR)psychostimulantsS6K (70-kDa ribosomal protein S6 kinase)transcriptomic (RNA-Seq)

Identifiers

PMID35250674
PMCPMC8894854
OpenAlexW4213064780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.