SynthesisFrontiers in physiology2022
Changes in Cytokines Concentration Following Long-Distance Running: A Systematic Review and Meta-Analysis.
Synthesis in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- The impact of exercise on inflammatory biomarkers: an umbrella review of systematic reviews and meta-analyses.Frontiers in immunology · 2026Pooled it
- Effects of Probiotic Supplementation on Immune and Inflammatory Markers in Athletes: A Meta-Analysis of Randomized Clinical Trials.Medicina (Kaunas, Lithuania) · 2022Pooled it
- The influence of exercise modality on the inflammatory response to high-intensity interval training.ImmunoHorizons · 2026Trial
- A preliminary study of lipid complex supplementation on fatty acid profile and blood antioxidant status after downhill running in athletes.Scientific reports · 2025Trial
- Enhancement of Interferon-γ Secretion byInternational journal of medical sciences · 2025Trial
- Direct Effects of Vitamin D Supplementation on Ultramarathon-Induced Changes in Kynurenine Metabolism.Nutrients · 2022Trial
- The Neurochemical Orchestra of the Runner's High: A Narrative Review of Neuromodulatory Mechanisms with a Focus on Endocannabinoids.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2026Review
- The Associations Between Habitual Dietary Fat Intake and Inflammatory Markers Among Marathon Runners: An Exploratory Study.Nutrients · 2026Article
- Oxy-Inflammatory Profile of Finishers and No-Finishers in an Extreme Ultra-Endurance Trail Race: The 866 km Transpyrénéa.International journal of molecular sciences · 2026Article
- 24-Hour Ultra-Marathon Running: A Narrative Review of Performance Factors and Physiological Impacts.Sports medicine - open · 2026Review
- (Ultra-)inflammation or adaptation? Comparison of different ultramarathon distances and their effect on the immune system.Frontiers in immunology · 2026Article
- Exercise as a modulator of systemic inflammation and oxidative stress biomarkers across clinical and healthy populations: an umbrella meta-analysis.BMC sports science, medicine & rehabilitation · 2025Article
- Impact of a single swimming session on inflammatory response and iron homeostasis in adolescent female athletes during the luteal phase.Scientific reports · 2025Article
- Running with rheumatoid arthritis: a qualitative study of Australian rheumatologists' perceptions and recommendations.BMJ open · 2025Article
- Influence of long-distance trail running on blood hemostasis at the World Mountain Trail Running Championship 2023-a pilot study.Research and practice in thrombosis and haemostasis · 2025Article
- Study of Blood Biomarkers in Athletes with Lower Gastrointestinal Symptoms After an Ultra-Trail Race.Journal of clinical medicine · 2025Article
- Exercise interventions for pulmonary function impairment: rehabilitation strategies from the acute phase to long-term sequelae.Frontiers in physiology · 2025Review
- Physical activity and glioblastoma: a paradigm shift in neuro-oncology therapy.Frontiers in oncology · 2025Review
- Does the guideline-based physical activity level for cardiovascular health also benefit periodontal health?Journal of dental sciences · 2024Article
- Manual therapy and exercise effects on inflammatory cytokines: a narrative overview.Frontiers in rehabilitation sciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-distance running is an exhausting effort for the whole organism. Prolonged aerobic exercise induces changes in inflammatory markers. However, predicting muscle damage in response has limitations in terms of selecting biomarkers used to measure inflammatory status. The present study conducts a systematic review and meta-analysis of articles focusing in ultra-marathon, marathon, and half-marathon and levels of cytokines. The search was conducted in PubMed, Web of Science, and Scopus databases, resulting in the inclusion of 76 articles. IL-6 was highlighted, evaluated in 62 studies and show increase in the standard mean difference (SMD): half-marathon (SMD -1.36; IC 95%: -1.82, -0.89, Ch
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.