Evidence map›Paper›PMID 35250536›Full record

ReviewFrontiers in aging neuroscience2022

Role of Specialized Pro-resolving Mediators in Reducing Neuroinflammation in Neurodegenerative Disorders.

Jana Ponce, Arzu Ulu, Corrine Hanson, Erin Cameron-Smith, John Bertoni, Jenna Wuebker, Alfred Fisher, Ka-Chun Siu, Vivien Marmelat, Jiri Adamec and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Jana PonceDivision of Medical Nutrition Education, College of Allied Health Professions, University of Nebraska Medical Center, Omaha, NE, United States.
Arzu UluDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, United States.
Corrine HansonDivision of Medical Nutrition Education, College of Allied Health Professions, University of Nebraska Medical Center, Omaha, NE, United States.
Erin Cameron-SmithDepartment of Neurological Sciences, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
John BertoniDepartment of Neurological Sciences, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
Jenna WuebkerDepartment of Pharmaceutical and Nutrition Care, Nebraska Medicine, Omaha, NE, United States.
Alfred FisherDepartment of Internal Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
Ka-Chun SiuDivision of Medical Nutrition Education, College of Allied Health Professions, University of Nebraska Medical Center, Omaha, NE, United States.
Vivien MarmelatDepartment of Biomechanics, College of Education, Health, and Human Sciences, University of Nebraska - Omaha, Omaha, NE, United States.
Jiri AdamecDepartment of Biochemistry, College of Arts and Sciences, University of Nebraska - Lincoln, Lincoln, NE, United States.
Danish BhattiDepartment of Neurological Sciences, College of Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
University of Nebraska Medical Center · USNebraska Medical Center · USUniversity of California, Riverside · USUniversity of Nebraska at Omaha · USUniversity of Nebraska–Lincoln · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative disorders that affect millions of individuals worldwide. As incidence of these conditions increases with age, there will undoubtedly be an increased prevalence of cases in the near future. Neuroinflammation is a hallmark in the development and progression of neurodegenerative diseases and prevention or resolution of chronic neuroinflammation may represent a novel approach to treatment. The present review highlights the potential of the anti-inflammatory and pro-resolving effects of polyunsaturated fatty acid (PUFA)-derived mediators (Specialized Pro-resolving Mediators-SPM) in neurodegenerative disorders. PUFA-derived SPM are biosynthesized in response to chemicals produced from acute inflammatory responses. Preclinical studies from both AD and PD models suggest a dysregulation of SPM and their receptors in neurological disorders. Decreased SPM may be due to inadequate substrate, an imbalance between SPM and pro-inflammatory mediators or a disruption in SPM synthesis. SPMs hold great promise for neuroprotection in AD by altering expression of pro-inflammatory genes, modulating macrophage function, serving as a biomarker for AD status, and promoting resolution of neuroinflammation. In PD, data suggest SPM are able to cross the blood-brain barrier, inhibit microglial activation and decrease induced markers of inflammation, possibly as a result of their ability to downregulate NFκB signaling pathways. Several

Indexed as

Alzheimer’s diseaseneurodegenerative disorderneuroinflammationomega-3 fatty acidsomega-6 fatty acidParkinson’s diseasepolyunsaturated fatty acidsspecialized pro-resolving lipid mediator (SPM)

Identifiers

PMID35250536
PMCPMC8891627
OpenAlexW4213168756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.