ReviewFrontiers in behavioral neuroscience2022
A Role for Serotonin in Modulating Opposing Drive and Brake Circuits of Impulsivity.
Review in Frontiers in behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Effects of oxycodone on tonic levels and phasic release of serotonin in the rat nucleus accumbens core.Bioelectrochemistry (Amsterdam, Netherlands) · 2026Article
- The Serotonin 1B Receptor Modulates Striatal Activity Differentially Based on Behavioral Context.eNeuro · 2026Article
- Association between the prognostic nutritional index and impulse control disorders in patients with early-stage Parkinson's disease.Frontiers in nutrition · 2026Article
- The serotonin 1B receptor modulates striatal activity differentially based on behavioral context.bioRxiv : the preprint server for biology · 2025Article
- Associations Between Gut Microbiota Composition and Impulse Control Disorders in Parkinson's Disease.International journal of molecular sciences · 2025Article
- Antidepressants in Bipolar Depression: From Neurotransmitter Mechanisms to Clinical Challenges.Actas espanolas de psiquiatria · 2025Review
- Molecular Pathways, Neural Circuits and Emerging Therapies for Self-Injurious Behaviour.International journal of molecular sciences · 2025Review
- Complementary roles of serotonin and dopamine in model-based learning.Current opinion in behavioral sciences · 2025Article
- The Relationship Between Impulsivity Traits and In Vivo Cerebral Serotonin Transporter and Serotonin 2A Receptor Binding in Healthy Individuals: A Double-Tracer PET Study with C-11 DASB and C-11 MDL100907.International journal of molecular sciences · 2024Article
- Beyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder.Molecular psychiatry · 2024Review
- Effects of chronic stress on cognitive function - From neurobiology to intervention.Neurobiology of stress · 2024Review
- Reward value and internal state differentially drive impulsivity and motivation.Behavioural brain research · 2024Article
- Temporal Framework and Biological Indicators of Non-Suicidal Self-Injury and Related Behaviours.The Malaysian journal of medical sciences : MJMS · 2024Article
- The Association of Antidepressant Use and Impulse Control Disorder in Parkinson's Disease.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Observational
- An integrative sensor of body states: how the mushroom body modulates behavior depending on physiological context.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Prefrontal serotonin depletion delays reversal learning and increases theta synchronization of the infralimbic-prelimbic-orbitofrontal prefrontal cortex circuit.Frontiers in pharmacology · 2024Article
- Pharmacological Mechanism of Ketamine in Suicidal Behavior Based on Animal Models of Aggressiveness and Impulsivity: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Prenatal maternal stress and offspring aggressive behavior: Intergenerational and transgenerational inheritance.Frontiers in behavioral neuroscience · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Impulsivity generally refers to a deficit in inhibition, with a focus on understanding the neural circuits which constitute the "brake" on actions and gratification. It is likely that increased impulsivity can arise not only from reduced inhibition, but also from a heightened or exaggerated excitatory "drive." For example, an action which has more vigor, or is fueled by either increased incentive salience or a stronger action-outcome association, may be harder to inhibit. From this perspective, this review focuses on impulse control as a competition over behavioral output between an initially learned response-reward outcome association, and a subsequently acquired opposing inhibitory association. Our goal is to present a synthesis of research from humans and animal models that supports this dual-systems approach to understanding the behavioral and neural substrates that contribute to impulsivity, with a focus on the neuromodulatory role of serotonin. We review evidence for the role of serotonin signaling in mediating the balance of the "drive" and "brake" circuits. Additionally, we consider parallels of these competing instrumental systems in impulsivity within classical conditioning processes (e.g., extinction) in order to point us to potential behavioral and neural mechanisms that may modulate the competing instrumental associations. Finally, we consider how the balance of these competing associations might contribute to, or be extracted from, our experimental assessments of impulsivity. A careful understanding of the underlying behavioral and circuit level contributions to impulsivity is important for understanding the pathogenesis of increased impulsivity present in a number of psychiatric disorders. Pathological levels of impulsivity in such disorders are likely subserved by deficits in the balance of motivational and inhibitory processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.