ArticleFrontiers in neural circuits2022
Brain Connectometry Changes in Space Travelers After Long-Duration Spaceflight.
Article in Frontiers in neural circuits, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The human brain in space: a meta-analysis of neuroimaging evidence.Frontiers in psychology · 2026Pooled it
- Effect of spaceflight experience on human brain structure, microstructure, and function: systematic review of neuroimaging studies.Brain imaging and behavior · 2024Pooled it
- Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight.Experimental physiology · 2026Review
- Gravity-awareness: a deep learning and LLM framework for predicting human adaptation to altered gravitational environments.Frontiers in psychology · 2026Article
- Space Oddity: microgravity as a neurocognitive catalyst for transformative consciousness experiences.Frontiers in psychology · 2026Article
- Neuromotor changes in postural control following bed rest.The Journal of physiology · 2026Review
- Effects of seasonal factors on brain function: Systematic review and future perspectives.iScience · 2025Article
- Neural changes in microgravity: Investigating the effects of aerospace environments.IBRO neuroscience reports · 2025Review
- Microgravity Therapy as Treatment for Decelerated Aging and Successful Longevity.International journal of molecular sciences · 2025Review
- Brains in space: impact of microgravity and cosmic radiation on the CNS during space exploration.Nature reviews. Neuroscience · 2025Review
- Navigating mental health in space: gut-brain axis and microbiome dynamics.Experimental & molecular medicine · 2025Review
- An Update on Neuroaging on Earth and in Spaceflight.International journal of molecular sciences · 2025Review
- A Hierarchical Mechanotransduction System: From Macro to Micro.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Cognitive performance in ISS astronauts on 6-month low earth orbit missions.Frontiers in physiology · 2024Article
- Toward an Etiology of Spaceflight Neuroplastic Syndrome: Evolutionary Science Leads to New Hypotheses and Program Priorities.NeuroSci · 2023Article
- Methods for assessing change in brain plasticity at night and psychological resilience during daytime between repeated long-duration space missions.Scientific reports · 2023Article
- Cognition in zero gravity: Effects of non-terrestrial gravity on human behaviour.Quarterly journal of experimental psychology (2006) · 2023Article
- Review
- Changes in working memory brain activity and task-based connectivity after long-duration spaceflight.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Impact of different ground-based microgravity models on human sensorimotor system.Frontiers in physiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Humans undergo extreme physiological changes when subjected to long periods of weightlessness, and as we continue to become a space-faring species, it is imperative that we fully understand the physiological changes that occur in the human body, including the brain. In this study, we present findings of brain structural changes associated with long-duration spaceflight based on diffusion magnetic resonance imaging (dMRI) data. Twelve cosmonauts who spent an average of six months aboard the International Space Station (ISS) were scanned in an MRI scanner pre-flight, ten days after flight, and at a follow-up time point seven months after flight. We performed differential tractography, a technique that confines white matter fiber tracking to voxels showing microstructural changes. We found significant microstructural changes in several large white matter tracts, such as the corpus callosum, arcuate fasciculus, corticospinal, corticostriatal, and cerebellar tracts. This is the first paper to use fiber tractography to investigate which specific tracts exhibit structural changes after long-duration spaceflight and may direct future research to investigate brain functional and behavioral changes associated with these white matter pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.