Evidence map›Paper›PMID 35250467›Full record

ArticleFrontiers in neuroscience2022

Deep Learning and Simulation for the Estimation of Red Blood Cell Flux With Optical Coherence Tomography.

Sabina Stefan, Anna Kim, Paul J Marchand, Frederic Lesage, Jonghwan Lee

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Sabina StefanSchool of Engineering, Brown University, Providence, RI, United States.
Anna KimDepartment of Neuroscience, Brown University, Providence, RI, United States.
Paul J MarchandDepartment of Electrical Engineering, École Polytechnique de Montréal, Montréal, QC, Canada.
Frederic LesageDepartment of Electrical Engineering, École Polytechnique de Montréal, Montréal, QC, Canada.
Jonghwan LeeSchool of Engineering, Brown University, Providence, RI, United States.
Brown University · USPolytechnique Montréal · CA

Funding

Long-Term Tracking of Cerebral Microvascular Structural and Functional Alterations between Normal and Alzheimer's AgingR01AG067228 · NIA · BROWN UNIVERSITY · PI LEE, JONGHWAN · 2020 to 2024
$1.8M
NIA NIH HHS R01 AG067228
6 · The paper itself

Abstract

We present a deep learning and simulation-based method to measure cortical capillary red blood cell (RBC) flux using Optical Coherence Tomography (OCT). This method is more accurate than the traditional peak-counting method and avoids any user parametrization, such as a threshold choice. We used data that was simultaneously acquired using OCT and two-photon microscopy to uncover the distribution of parameters governing the height, width, and inter-peak time of peaks in OCT intensity associated with the passage of RBCs. This allowed us to simulate thousands of time-series examples for different flux values and signal-to-noise ratios, which we then used to train a 1D convolutional neural network (CNN). The trained CNN enabled robust measurement of RBC flux across the entire network of hundreds of capillaries.

Indexed as

capillary flowdeep learningmicrovascular networkRBC fluxsimulation

Identifiers

PMID35250467
PMCPMC8891630
OpenAlexW4213049417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.