ArticleFrontiers in neuroscience2022
Therapeutic Role of Repetitive Transcranial Magnetic Stimulation in Alzheimer's and Parkinson's Disease: Electroencephalography Microstate Correlates.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Pooled it
- The Functional Aspects of Resting EEG Microstates: A Systematic Review.Brain topography · 2024Pooled it
- Microstates and connectivity states reveal task-related network reorganization in Alzheimer's disease patients.Clinical neurophysiology practice · 2026Article
- Resting-state EEG microstates link neural dynamics to fluid intelligence in mild cognitive impairment.Frontiers in aging neuroscience · 2026Article
- EEG microstates, spectral analysis, and risk prediction in epilepsy comorbid with mild cognitive impairment: alteration in intrinsic brain activity.Journal of translational medicine · 2025Article
- EEG Microstates Signatures of rTMS Response Over the lDLPFC: A Band-Specific Analysis.Brain topography · 2025Article
- Transcranial Magnetic Stimulation as a Diagnostic Tool in Mild Cognitive Impairment: A Systematic Review.Brain sciences · 2025Review
- Apathy in Parkinson's Disease: EEG Microstate Characteristics.Brain topography · 2025Article
- The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Alpha rhythm and Alzheimer's disease: Has Hans Berger's dream come true?Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Review
- Targeting the parietal memory network with tDCS in MCI: study protocol for a randomized controlled trial.Frontiers in human neuroscience · 2025Article
- The Adaptive Role of Entorhinal Cortical Thickness in Post-COVID 19 Cognitive Impairment.Noro psikiyatri arsivi · 2025Article
- A Task-Related EEG Microstate Clustering Algorithm Based on Spatial Patterns, Riemannian Distance, and a Deep Autoencoder.Brain sciences · 2024Article
- Heterogeneous Brain Dynamics Between Acute Cerebellar and Brainstem Infarction.Cerebellum (London, England) · 2024Article
- Decoding the Preparation Stage of Target Shooting under Audiovisual Restricted Conditions: Investigating Neural Mechanisms Using Microstate Analysis.Brain topography · 2024Article
- EEG-Meta-Microstates: Towards a More Objective Use of Resting-State EEG Microstate Findings Across Studies.Brain topography · 2024Article
- The Use of Transcranial Magnetic Stimulation in Attention Optimization Research: A Review from Basic Theory to Findings in Attention-Deficit/Hyperactivity Disorder and Depression.Life (Basel, Switzerland) · 2024Review
- Pre-treatment frontal beta events are associated with executive dysfunction improvement after repetitive transcranial magnetic stimulation for depression: A preliminary report.Journal of psychiatric research · 2023Article
- [Advances in methods and applications of electroencephalogram microstate analysis].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe microstate analysis is a method to convert the electrical potentials on the multi-channel electrode array to topographical electroencephalography (EEG) data. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive method that can modulate brain networks. This study explores the pathophysiological changes through microstate analysis in two different neurodegenerative diseases, Alzheimer's (AD) and Parkinson's disease (PD), characterized by motor and cognitive symptoms and analysis the effect of rTMS on the impaired cognitive and motor functions. MATERIALS AND
methodsWe included 18 AD, 8 PD patients, and 13 age-matched controls. For both groups, we applied 5 Hz rTMS on the left pre-SMA in PD patients while 20 Hz rTMS on the left lateral parietal region in AD patients. Each patient was re-evaluated 1 week after the end of the sessions, which included a detailed clinical evaluation and measurement of EEG microstates.
resultsAt the baseline, the common findings between our AD and PD patients were altered microstate (MS) B, MS D durations and transition frequencies between MS A-MS B, MS C-MS D while global explained variance (GEV) ratio and the extent and frequency of occurrence of MS A, MS B, and MS D were separately altered in AD patients. Although no specific microstate parameter adequately differentiated between AD and PD patients, we observed significant changes in MS B and MS D parameters in PD patients. Further, we observed that Mini-Mental State Examination (MMSE) performances were associated with the transition frequencies between MS A-MS B and MS C-MS D and GEV ratio. After left parietal rTMS application, we have observed significantly increased visual memory recognition and clock drawing scores after left parietal rTMS application associated with improved microstate conditions prominent, especially in the mean duration of MS C in AD patients. Also, pre-SMA rTMS resulted in significant improvement in motor scores and frequency of transitions from MS D to MS C in PD patients.
conclusionThis study shows that PD and AD can cause different and similar microstate changes that can be modulated through rTMS, suggesting the role of MS parameters and rTMS as a possible combination in monitoring the treatment effect in neurodegenerative diseases.
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