ArticleInternational journal of general medicine2022
High Low-Density Lipoprotein Cholesterol Levels are Associated with Osteoporosis Among Adults 20-59 Years of Age.
Article in International journal of general medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Potential causal effect of SLE on osteoporosis, and the mediation effect: a Mendelian randomisation study.Lupus science & medicine · 2025Pooled it
- Association between baseline lipid levels and re-fracture after percutaneous vertebroplasty for osteoporotic vertebral compression fractures: a retrospective cohort study.Journal of orthopaedic surgery and research · 2026Article
- Non-linear associations between UHR and bone mineral density in US adults: NHANES 2017-2018.European journal of medical research · 2025Article
- Characterizing the Lipid Profile in Patients with Vertebral or Hip Fragility Fractures: A Hospital-Based Descriptive Study.Journal of clinical medicine · 2025Article
- Metabolic Rewiring and Post-Translational Modifications: Unlocking the Mechanisms of Bone Turnover in Osteoporosis.Aging and disease · 2025Review
- Fracture Risk Assessment in Metabolic Syndrome in Terms of Secondary Osteoporosis Potential. A Narrative Review.Calcified tissue international · 2025Review
- Association between life's essential 8 and bone mineral density among adults aged 20-59 years.Scientific reports · 2025Article
- Associations of Serum Lipid Traits With Fracture and Osteoporosis: A Prospective Cohort Study From the UK Biobank.Journal of cachexia, sarcopenia and muscle · 2024Article
- The Causal Relationship between PCSK9 Inhibitors and Osteoporosis Based on Drug-Targeted Mendelian Combined Mediation Analysis.Calcified tissue international · 2024Article
- Non-linear association of atherogenic index of plasma with bone mineral density a cross-sectional study.Lipids in health and disease · 2024Article
- Crosstalk between Lipid Metabolism and Bone Homeostasis: Exploring Intricate Signaling Relationships.Research (Washington, D.C.) · 2024Article
- Cardiometabolic index is associated with increased bone mineral density: a population-based cross-sectional study.Frontiers in public health · 2024Article
- Race and Gender Differences in the Associations Between Cadmium Exposure and Bone Mineral Density in US Adults.Biological trace element research · 2023Article
- Associations between weight-adjusted waist index and bone mineral density: results of a nationwide survey.BMC endocrine disorders · 2023Article
- Associations between weight-adjusted waist index and fractures: a population-based study.Journal of orthopaedic surgery and research · 2023Article
- The Paradoxical Association of Lipids with Survival and Walking Ability of Hip Fractures in Geriatric Patients After Surgery: A 1-Year Follow-Up Study.International journal of general medicine · 2023Article
- Article
- Association of family income to poverty ratio and vibration-controlled transient elastography quantified degree of hepatic steatosis in U.S. adolescents.Frontiers in endocrinology · 2023Article
- BMI, socioeconomic status, and bone mineral density in U.S. adults: Mediation analysis in the NHANES.Frontiers in nutrition · 2023Article
- Association of urinary caffeine and caffeine metabolites with bone mineral density in children and adolescents.Medicine · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerum lipids are highly inheritable and play a major role in bone health. However, the relationship between low-density lipoprotein cholesterol (LDL-C) and bone mineral density (BMD) remains uncertain. The goal of this study was to see if there was a link between LDL-C levels and BMD in persons aged 20 to 59.
methodsUsing data from the National Health and Nutrition Examination Survey (NHANES) 2011-2018, multivariate logistic regression models were utilized to investigate the association between LDL-C and lumbar BMD. Fitted smoothing curves and generalized additive models were also used.
resultsThe analysis included a total of 4909 adults. After controlling for various variables, we discovered that LDL-C was negatively linked with lumbar BMD. The favorable connection of LDL-C with lumbar BMD was maintained in subgroup analyses stratified by gender and race in both males and females, Whites and Mexican Americans, but not in Blacks and other races. The relationship between LDL-C and lumbar BMD in other races was an inverted U-shaped curve with the inflection point: 2.327 (mmol/L).
conclusionIn people aged 20 to 59, our research discovered a negative relationship among LDL-C and lumbar BMD. Among races other than Whites, Blacks, Mexican Americans, this relationship followed an inverted U-shaped curve (inflection point: 2.327mmol/L). LDL-C measurement might be used as a responsive biomarker for detecting osteoporosis early and guiding therapy.
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