ArticleJournal of inflammation research2022
Combination of Uric Acid and Pro-Inflammatory Cytokines in Discriminating Patients with Gout from Healthy Controls.
Article in Journal of inflammation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 26 citations in OpenAlex.
- Clinical and inflammatory factors associated with prevalent gout in a Brazilian hospital population.Clinics (Sao Paulo, Brazil) · 2026Article
- Previous schistosome infection and the risk of incident hyperuricemia: A prospective cohort study.PLoS neglected tropical diseases · 2026Article
- Integrated discovery and mechanistic characterization of xanthine oxidase inhibitory peptides from sheep Milk.Food chemistry: X · 2026Article
- Development and validation of a risk models for gout in patients with diabetic kidney disease.BMC endocrine disorders · 2026Article
- Article
- Exploratory study on the efficacy of Lingze mixture in gouty arthritis rats and preliminary analysis of its potential mechanisms via transcriptome sequencing.Scientific reports · 2025Article
- Advancing early detection of gastric cancer through serum cytokine profiling.World journal of clinical oncology · 2025Article
- Higher uric acid associated with elevated IL‑6 and IL‑1β levels in older inpatients: a cross‑sectional study.Rheumatology international · 2025Article
- The anti-hyperuricemia potential of bioactive natural products and extracts derived from traditional Chinese medicines: A review and perspective.Journal of pharmaceutical analysis · 2025Review
- Serum pro-inflammatory cytokines as potential biomarkers for the diagnosis of gastric carcinoma.World journal of clinical oncology · 2025Article
- Investigating the relationship between body mass index, hypertension, and new-onset hyperuricemia in a Chinese repeat health checkup population.BMC public health · 2025Article
- Impact of serum uric acid to high-density lipoprotein cholesterol ratio on short-term outcomes in acute decompensated heart failure: a cohort study in Jiangxi Province, China.Frontiers in endocrinology · 2025Article
- Association between magnesium depletion score and prevalence of hyperuricemia in American adults: a study based on NHANES 2007-2018.Frontiers in endocrinology · 2025Article
- Uric Acid: A Biomarker and Pathogenic Factor of Affective Disorders and Neurodegenerative Diseases.Current pharmaceutical design · 2025Review
- Impact of gout on colorectal cancer and its survival: a two-sample Mendelian randomization study.Discover oncology · 2024Article
- Causal relationship between serum uric acid levels and male infertility: a bidirectional two-sample Mendelian randomization study.Translational andrology and urology · 2024Article
- Hyperuricemia and its related diseases: mechanisms and advances in therapy.Signal transduction and targeted therapy · 2024Review
- Correlation between gout and dry eye disease.International ophthalmology · 2024Review
- Upadacitinib sustained-release tablets for the treatment of chronic refractory gouty arthritis: a case report and literature review.Frontiers in medicine · 2024Article
- Alterations in articular cartilage frictional properties in the setting of acute gouty arthritis.PloS one · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of present study was to explore whether the combination of serum uric acid and pro-inflammatory cytokines could improve the accuracy of diagnosis of gout.
methodsA total of 94 patients with gout were selected as the patient group, and 52 healthy subjects were selected as the control group. Serum levels of uric acid and pro-inflammatory cytokines (C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)) were measured in both groups. Correlation between serum uric acid and pro-inflammatory cytokines was assessed using Pearson correlation analysis. The area under curve (AUC) of CRP, IL-6, TNF-α combined with uric acid for the diagnosis of gout were evaluated by receiver operating characteristic (ROC) curve method.
resultsCompared with the control group, the levels of serum uric acid, CRP, TNF-α and IL-6 were significantly increased in the patients. Moreover, there was a positive correlation between serum uric acid and CRP (
conclusionThe combination of serum uric acid and pro-inflammatory cytokines could improve the accuracy of diagnosis of gout.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.