Evidence map›Paper›PMID 35249931›Full record

ArticleJournal of atherosclerosis and thrombosis2023

Additive Effects of Drinking Habits and a Susceptible Genetic Polymorphism on Cholesterol Efflux Capacity.

Erika Matsumoto, Kentaro Oniki, Ami Ota-Kontani, Yuri Seguchi, Yuki Sakamoto, Tetsuya Kaneko, Tadashi Imafuku, Hitoshi Maeda, Hiroshi Watanabe, Toru Maruyama and 5 more

Open access · diamondAbstract read
In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Erika MatsumotoDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University.
Kentaro OnikiDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University.
Ami Ota-KontaniDepartment of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute.
Yuri SeguchiDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University.
Yuki SakamotoDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University.
Tetsuya KanekoDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University.
Tadashi ImafukuDepartment of Molecular Pathophysiology, Institute of Advanced Medicine, Wakayama Medical University.
Hitoshi MaedaDepartment of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University.
Hiroshi WatanabeDepartment of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University.
Toru MaruyamaDepartment of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University.
Yasuhiro OgataJapanese Red Cross Kumamoto Health Care Center.
Minoru YoshidaJapanese Red Cross Kumamoto Health Care Center.
Mariko Harada-ShibaDepartment of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute.
Junji SaruwatariDivision of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University.
Masatsune OguraDepartment of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute.
Kumamoto University · JPNational Cerebral and Cardiovascular Center · JPJapanese Red Cross Kumamoto Hospital · JPWakayama Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsHigh levels of high-density lipoprotein cholesterol (HDL-C) are not necessarily effective in preventing atherosclerotic cardiovascular disease, and cholesterol efflux capacity (CEC) has attracted attention regarding HDL functionality. We aimed to elucidate whether drinking habits are associated with CEC levels, while also paying careful attention to confounding factors including serum HDL-C levels, other life style factors, and rs671 (

methodsA cross-sectional study was performed in 505 Japanese male subjects who were recruited from a health screening program. Associations of HDL-C and CEC levels with drinking habits and ALDH2 genotypes were examined.

resultsThe genotype frequencies of ALDH2

conclusionsOur results suggest that heavy drinking habits may tend to decrease CEC levels, and in the ALDH2

Indexed as

Alcohol DrinkingAldehyde Dehydrogenase, MitochondrialCholesterol, HDLCross-Sectional StudiesHumansMalePolymorphism, GeneticAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanCholesterol, HDLAlcohol consumptionAldehyde dehydrogenase 2Cholesterol efflux capacityDrinking habitHigh-density lipoprotein cholesterol

Identifiers

PMID35249931
PMCPMC9899708
OpenAlexW4214952256

What OpenQuestion holds

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LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.