ReviewThe Korean journal of internal medicine2022
Emotional and cognitive changes in chronic kidney disease.
Review in The Korean journal of internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
- The effect of Sudoku puzzle solving on memory and anxiety of hemodialysis patients: a randomized controlled clinical trial.International urology and nephrology · 2026Trial
- Vitamin D Status and Depressive Symptoms in Patients Undergoing Hemodialysis: A Cross-Sectional Study.Nutrients · 2026Article
- Sulforaphane mitigates behavioral deficits in experimental chronic kidney disease through regulation of Nrf2/NLRP3 inflammasome.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- The Kidney-Brain Axis in Chronic Kidney Disease: Uremic Toxins, Cognitive Decline, Mechanistic Pathways, Biomarkers and Therapeutic Perspectives.Biomedicines · 2026Review
- Serum Creatinine Clearance and Cognitive Function in Older Adults: Mediating Effects of Systemic Inflammatory Response Index.Brain and behavior · 2026Article
- Quality of life, sleep quality, and psychological wellbeing of patients with chronic kidney disease in Sabaragamuwa Province, Sri Lanka: a descriptive cross-sectional study.Scientific reports · 2026Article
- Prevalence and Spirometric Transitions of PRISm and Obstruction: A Population-Based Study.Respirology (Carlton, Vic.) · 2026Article
- Assessment of Depression and Anxiety in Hemodialysis Patients Undergoing VR Therapy-Pilot Study.Journal of clinical medicine · 2026Article
- Cognitive impairment and depressive symptoms to predict renal outcome and mortality in older adult patients.PloS one · 2026Article
- Gender-based distribution of depression and anxiety following acute coronary syndrome in the Turkish population: are women at higher risk?BMC cardiovascular disorders · 2025Observational
- Drivers and mechanisms of cognitive decline in chronic kidney disease.Nature reviews. Nephrology · 2025Review
- Cognitive impairment and health outcomes in non-dialysis chronic kidney disease: a systematic review and meta-analysis.Clinical kidney journal · 2025Article
- A second act for spironolactone: cognitive benefits in renal dysfunction - a critical review.Metabolic brain disease · 2025Review
- Early detection of cognitive impairment in end-stage renal disease patients undergoing hemodialysis: insights from Resting-State functional connectivity analysis.BMC nephrology · 2025Article
- Early-stage chronic kidney disease as a risk factor for suicide: a nationwide observational cohort study.Journal of nephrology · 2025Observational
- Behind the Healing: Exploring the Psychological Battles of Kidney Transplant Patients: A Qualitative Insight.Health science reports · 2025Article
- Assessment of Cognitive Functions in Multimorbid Patients in Lithuanian Primary Care Settings: A Cross-Sectional Study Using MMSE and LT-GPCOG.Medicina (Kaunas, Lithuania) · 2025Article
- Cognitive impairment assessed by static and dynamic changes of spontaneous brain activity during end stage renal disease patients on early hemodialysis.Frontiers in neurology · 2025Article
- Integrative approaches to depression in end-stage renal disease: insights into mechanisms, impacts, and pharmacological strategies.Frontiers in pharmacology · 2025Review
- Study on the Influence and Mechanism of Resveratrol on Cognitive Impairment in Chronic Kidney Disease Rats Through Regulating Gut Microbiota and the TLR4/NFκB Pathway.Journal of inflammation research · 2025Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic kidney disease (CKD) leads to cognitive impairment and emotional changes. However, the precise mechanism underlying the crosstalk between the kidneys and the nervous system is not fully understood. Inflammation and cerebrovascular disease can influence the development of depression in CKD. CKD is one of the strongest risk factors for cognitive impairment. Moreover, cognitive impairment occurs in CKD as patients experience the dysregulation of several brain functional domains due to damage caused to multiple cortical regions and to subcortical modulatory neurons. The differences in structural brain changes between CKD and non-CKD dementia may be attributable to the different mechanisms that occur in CKD. The kidney and brain have similar anatomical vascular systems, which may be susceptible to traditional risk factors. Vascular factors are assumed to be involved in the development of cognitive impairment in patients with CKD. Vascular injury induces white matter lesions, silent infarction, and microbleeds. Uremic toxins may also be directly related to cognitive impairment in CKD. Many uremic toxins, such as indoxyl sulfate, are likely to have an impact on the central nervous system. Further studies are required to identify therapeutic targets to prevent changes in the brain in patients with CKD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.