ArticleDiabetes & metabolism journal2022
Iron Overload and the Risk of Diabetes in the General Population: Results of the Chinese Health and Nutrition Survey Cohort Study.
Article in Diabetes & metabolism journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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24 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Quantitative susceptibility mapping for iron monitoring of multiple subcortical nuclei in type 2 diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Prediabetes Subtypes with Divergent Iron Metabolism Profiles: A Cluster Analysis from Two Cohorts in the United States and China.Biological trace element research · 2026Article
- Iron Overload: Pathophysiology, Diagnosis and Monitoring.International journal of laboratory hematology · 2026Review
- Sex-specific associations of urinary zinc, iron, and zinc-to-iron ratio with obesity indicators and phenotypes.European journal of nutrition · 2026Article
- Endogenous iron biomineralization in the mouse spleen of metabolic diseases.Fundamental research · 2026Article
- Ferroptosis in diabetes mellitus and its complications: overview of clinical and preclinical research.Cell death discovery · 2025Review
- The nomenclature of fatty liver disease and its impact on obesity traits, insulin resistance, and hepatic fibrosis.Lipids in health and disease · 2025Article
- Article
- Differences in nonheme iron absorption between healthy adults of East Asian or Northern European ancestry from the Iron Genes in East Asian and Northern European Adults Study (FeGenes): A cross-sectional stable iron isotope study.The American journal of clinical nutrition · 2025Article
- Characterization of iron status biomarkers and hematological indices among young adults of East Asian or Northern European ancestry: A cross-sectional analysis from the Iron Genes in East Asian and Northern European Adults Study (FeGenes).The American journal of clinical nutrition · 2025Article
- Role of nutrition in diabetes mellitus and infections.World journal of clinical cases · 2025Article
- Effect of Lifestyle Intervention on the Mobilization of Fat Depots and Organ Iron Deposition in Individuals with Obesity: A Prospective Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Research on the Relationship Between Ectopic Fat and Iron Deposition in the Liver and Pancreas, with Glucose Metabolism in Elderly Obese Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- The Association Between Dietary Iron, the SNP of the JAZF1 rs864745, and Glucose Metabolism in a Chinese Population.Nutrients · 2024Article
- Mobile Application and Machine Learning-Driven Scheme for Intelligent Diabetes Progression Analysis and Management Using Multiple Risk Factors.Bioengineering (Basel, Switzerland) · 2024Article
- Article
- Association between serum iron and liver transaminases based on a large adult women population.Journal of health, population, and nutrition · 2023Article
- Epidemiological and transcriptome data identify potential key genes involved in iron overload for type 2 diabetes.Diabetology & metabolic syndrome · 2023Article
- Article
- Iron overload induces islet β cell ferroptosis by activating ASK1/P-P38/CHOP signaling pathway.PeerJ · 2023Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundRecent studies have found that there are significant associations between body iron status and the development of diabetes. In the present study, we aimed to analyze the association among iron overload (IO), insulin resistance (IR), and diabetes in Chinese adults, and to explore the sex difference.
methodsMen and women (age >19 years) who participated in the Chinese Health and Nutrition Survey and did not have diabetes at baseline were followed between 2009 and 2015 (n=5,779). Over a mean of 6 years, 75 participants were diagnosed with incident diabetes. Logistic regression was used to assess the risk factors associated with IO. Cox proportional hazard regression was used to estimate the risk of incident diabetes and to determine whether the risk differed among subgroups. Causal mediation analysis (CMA) was used to explore the mechanism linking IO and diabetes.
resultsAccording to sex-stratified multivariable-adjusted Cox proportional hazards regression, IO increased the risk of incident diabetes. Women with IO had a higher risk of diabetes than men. Subgroup analysis with respect to age showed that the association between IO and diabetes was stronger in older women and younger men (P<0.001). CMA showed that liver injury (alanine transaminase) and lipid metabolism abnormalities (triglyceride, apolipoprotein B) contributed to the association between IO and diabetes.
conclusionIO is associated with diabetes and this association is sex-specific. IO may indirectly induce IR via liver injury and lipid metabolism abnormalities, resulting in diabetes.
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