Evidence map›Paper›PMID 35249258›Full record

ArticleJournal of cellular and molecular medicine2022

Analyses of erythropoiesis from embryonic stem cell-CD34

Shihui Wang, Huizhi Zhao, Huan Zhang, Chengjie Gao, Xinhua Guo, Lixiang Chen, Cheryl Lobo, Karina Yazdanbakhsh, Shijie Zhang, Xiuli An

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. ReducedInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Erythroblast enucleation at a glance.Journal of cell science · 2024
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. The role of GATA2 in adult hematopoiesis and cell fate determination.Frontiers in cell and developmental biology · 2023
    Review
  13. Analyses of erythropoiesis from embryonic stem cell-CD34Journal of cellular and molecular medicine · 2022
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Shihui WangSchool of Life Sciences, Zhengzhou University, Zhengzhou, China.
Huizhi ZhaoSchool of Life Sciences, Zhengzhou University, Zhengzhou, China.
Huan ZhangLaboratory of Membrane Biology, New York Blood Center, New York, New York, USA.
Chengjie GaoLaboratory of Membrane Biology, New York Blood Center, New York, New York, USA.
Xinhua GuoLaboratory of Membrane Biology, New York Blood Center, New York, New York, USA.
Lixiang ChenSchool of Life Sciences, Zhengzhou University, Zhengzhou, China.
Cheryl LoboLaboratory of Blood Borne Parasites, New York Blood Center, New York, New York, USA.
Karina YazdanbakhshLaboratory of Complement Biology, New York Blood Center, New York, New York, USA.
Shijie ZhangSchool of Life Sciences, Zhengzhou University, Zhengzhou, China.
Xiuli AnLaboratory of Membrane Biology, New York Blood Center, New York, New York, USA.
New York Blood Center · USZhengzhou University · CN

Funding

Sickle cell bone marrow niche and regulation of platelet activation and erythropoiesisP01HL149626 · NHLBI · NEW YORK BLOOD CENTER · PI Karina Yazdanbakhsh · 2020 to 2026
$24.4M
Use of forward Genetic approaches to identify Babesia receptorsR01HL140625 · NHLBI · NEW YORK BLOOD CENTER · PI AN, XIULI, LOBO, CHERYL ANN · 2018 to 2021
$2.8M
National Natural Science Foundation of China 81700102National Natural Science Foundation of China 81870094National Natural Science Foundation of China 81870095National Natural Science Foundation of China U1804282NHLBI NIH HHS P01 HL149626NHLBI NIH HHS R01 HL140625Science and Technology Research Project of Henan 202102310040
6 · The paper itself

Abstract

Red blood cells (RBCs) generated ex vivo have the potential to be used for transfusion. Human embryonic stem cells (ES) and induced pluripotent stem cells (iPS) possess unlimited self-renewal capacity and are the preferred cell sources to be used for ex vivo RBC generation. However, their applications are hindered by the facts that the expansion of ES/iPS-derived erythroid cells is limited and the enucleation of ES/iPS-derived erythroblasts is low compared to that derived from cord blood (CB) or peripheral blood (PB). To address this, we sought to investigate the underlying mechanisms by comparing the in vitro erythropoiesis profiles of CB CD34

Indexed as

ErythropoiesisFetal BloodAntigens, CD34Cell DifferentiationChromatinEmbryonic Stem CellsErythroid CellsHumansAntigens, CD34ChromatinATAC-SeqenucleationerythropoiesisRNA-Seq

Identifiers

PMID35249258
PMCPMC8995447
OpenAlexW4220791536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.