Evidence map›Paper›PMID 35249166›Full record

ArticleMolecular neurobiology2022

Sox10 Gene Is Required for the Survival of Saccular and Utricular Hair Cells in a Porcine Model.

Jing-Cui Qi, Qing-Qing Jiang, Long Ma, Shuo-Long Yuan, Wei Sun, Li-Sheng Yu, Wei-Wei Guo, Shi-Ming Yang

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Jing-Cui QiDepartment of Otorhinolaryngology, Head and Neck Surgery, People's Hospital, Peking University, Beijing, People's Republic of China.
Qing-Qing JiangCollege of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, 100853, China.
Long MaPLA Rocket Force Characteristic Medical Center Department of Stomatology, Beijing, China.
Shuo-Long YuanCollege of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, 100853, China.
Wei SunDepartment of Communicative Disorders and Sciences, Center for Hearing and Deafness, The State University of New York at Buffalo, Buffalo, NY, USA.
Li-Sheng YuDepartment of Otorhinolaryngology, Head and Neck Surgery, People's Hospital, Peking University, Beijing, People's Republic of China. lisheng_peking@163.com.
Wei-Wei GuoCollege of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, 100853, China. gwent001@163.com.
Shi-Ming YangCollege of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, 100853, China. shm_yang@163.com.ORCID http://orcid.org/0000-0002-7808-2566
Ministry of Education of the People's Republic of China · CNPeking University · CNChinese PLA General Hospital · CNUniversity at Buffalo, State University of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathological changes of the cochlea and hearing loss have been well addressed in Waardenburg syndrome (WS). However, the vestibular organ malformation in WS is still largely unknown. In this study, the differentiation and development of vestibular sensory epithelium and vestibular function caused by SOX10 mutation, a critical gene induces WS, have been studied in minature pig model. Degeneration of vestibular hair cells was found in this Sox10 mutation porcine model. Inner ear phenotype of the SOX10

Indexed as

DeafnessVestibule, LabyrinthAnimalsCochleaHair Cells, AuditorySaccule and UtricleSwineMiniature porcine modelSacculeSox10UtricleWaardenburg syndrome

Identifiers

PMID35249166
OpenAlexW4221011389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.