Evidence map›Paper›PMID 35249162›Full record

ArticleEsophagus : official journal of the Japan Esophageal Society2022

Clinical presentation and therapeutic outcome of patients with jackhammer esophagus-a multicenter cohort study in Japan.

Hiroko Hosaka, Noriyuki Kawami, Noriaki Manabe, Shiko Kuribayashi, Hiroki Sato, Yasushi Funaki, Maki Ayaki, Ken Hara, Chise Ueda, Tomoaki Matsumura and 10 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Esophagus : official journal of the Japan Esophageal Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 16 institutions in 1 country.

Hiroko HosakaDepartment of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi Maebashi, Gunma, 371-8511, Japan. hhosaka@gunma-u.ac.jp.ORCID 0000-0002-3483-5351
Noriyuki KawamiDepartment of Gastroenterology, Nippon Medical School Graduate School of Medicine, Bunkyo-Ku Tokyo, Japan.
Noriaki ManabeDivision of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki, Japan.
Shiko KuribayashiDepartment of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi Maebashi, Gunma, 371-8511, Japan.
Hiroki SatoDivision of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, Niigata, Japan.
Yasushi FunakiDepartment of Gastroenterology, Aichi Medical University School of Medicine, Nagakute, Japan.
Maki AyakiDivision of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki, Japan.
Ken HaraDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Chise UedaDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Tomoaki MatsumuraDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Yasuhiro FujiwaraDepartment of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Masafumi WadaDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Maiko KishinoDepartment of Gastroenterological Endoscopy, Tokyo Women's Medical University, Shinjuku-ku Tokyo, Japan.
Fumiaki YanoDepartment of Surgery, The Jikei University School of Medicine, Minato-ku Tokyo, Japan.
Tatsuhiro MasaokaDivision of Gastroentrology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku Tokyo, Japan.
Norihisa IshimuraSecond Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Japan.
Junichi AkiyamaDepartment of Gastroenterology, National Center for Global Health and Medicine, Shinjuku-ku Tokyo, Japan.
Yorinari OchiaiDepartment of Gastroenterology, Toranomon Hospital, Minato-ku Tokyo, Japan.
Toshio UraokaDepartment of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi Maebashi, Gunma, 371-8511, Japan.
Katsuhiko IwakiriDepartment of Gastroenterology, Nippon Medical School Graduate School of Medicine, Bunkyo-Ku Tokyo, Japan.
Gunma University · JPKawasaki Medical School · JPNippon Medical School · JPAichi Medical University · JPChiba University · JPHyogo Medical University · JPJikei University School of Medicine · JPKeio University · JPKobe University · JPKyushu University · JPNational Center for Global Health and Medicine · JPNiigata University Medical and Dental Hospital · JPOsaka City University · JPShimane University · JPTokyo Women's Medical University · JPToranomon Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundJackhammer esophagus (JE) is a hypercontractile esophageal motility disorder diagnosed using high-resolution manometry (HRM). We sought to determine the clinical presentation and therapeutic data of patients with JE in Japan.

methodsThe study included patients with JE, diagnosed through HRM performed for suspicious esophageal motility disorders. Demographics, esophagogastroduodenoscopy, radiology, and therapy data were collected from patient charts.

resultsAmong the 4,412 HRM tests performed, 89 patients (61.6 ± 13.4 years; 64 males, 25 females) were diagnosed with JE (2.0%). Dysphagia was the most frequent symptom (80%), followed by chest pain (40%) and heartburn (25%). Esophagogastroduodenoscopy showed abnormal findings in 32% of patients: corkscrew/rosary beads appearance in 26%, narrowing in 11%. Eosinophilic infiltration (> 15 eosinophils/high power field) was diagnosed in 21%. Esophagography showed abnormal findings in 9% of the patients. For the initial therapy, 47 patients received medical treatment followed by peroral endoscopic myotomy (21 patients) and laparoscopic myotomy (two patients). Thirteen patients did not receive any treatment and 10 of those (77%) reported spontaneous resolution of symptoms. Patients who required invasive treatment experienced severe disability in their quality of life and greater maximal distal contractile integral than those who did not.

conclusionsHRM showed that the prevalence of JE was very low (2%). Esophagogastroduodenoscopy revealed some characteristic features of JE in patients. Some patients showed improvement of symptoms without invasive treatments. Follow-up with/without medical treatment should be considered before performing invasive treatment in patients whose distal contractile integral is relatively low and the quality of life is not impaired.

Indexed as

Esophageal Motility DisordersQuality of LifeCohort StudiesFemaleHumansJapanMaleTreatment OutcomeChest painDysphagiaEosinophilic esophagusEsophageal motility disordersManometry

Identifiers

PMID35249162
PMCPMC9166863
OpenAlexW4220898228

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.