Trial reportEuropean journal of nutrition2022
The effect of Bacillus coagulans Unique IS-2 supplementation on plasma amino acid levels and muscle strength in resistance trained males consuming whey protein: a double-blind, placebo-controlled study.
Trial report in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effects of combined protein and probiotic supplementation on physical performance and body composition: a Bayesian multilevel meta-analysis of randomized controlled trials.Frontiers in nutrition · 2026Pooled it
- Efficacy of probiotic supplements in the treatment of sarcopenia: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Impact of probiotics on muscle mass, muscle strength and lean mass: a systematic review and meta-analysis of randomized controlled trials.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Trial
- Efficacy ofNutrients · 2024Trial
- The probioticGut microbesTrial
- Article
- The Role of the Gut Microbiome and Probiotics in Sports Performance: A Narrative Review Update.Nutrients · 2025Review
- Effects ofLife (Basel, Switzerland) · 2025Article
- Probiotic supplementation for optimizing athletic performance: current evidence and future perspectives for microbiome-based strategies.Frontiers in nutrition · 2025Review
- Review
- An Updated View of the Effect of Probiotic Supplement on Sports Performance: A Detailed Review.Current nutrition reports · 2024Review
- Genetic and Phenotypic Characterization ofMicroorganisms · 2024Article
- Health benefits and risks of fermented foods-the PIMENTO initiative.Frontiers in nutrition · 2024Review
- A systematic scoping review of study methodology for randomized controlled trials investigating probiotics in athletic and physically active populations.Journal of sport and health science · 2024Article
- Progress of research and application ofFrontiers in cellular and infection microbiology · 2024Review
- Preclinical Safety Assessment ofMicroorganisms · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of the present study was to assess the effect of Bacillus coagulans Unique IS-2 supplementation on absorption and utilization of protein in resistance-trained males.
methodsIn this double blind, placebo-control trial, resistance-trained males (21.08 ± 2.84 years) were randomized to consume, either 20 g of whey protein powder {80% whey protein concentrate (WPC80), amounting to 15.4 g protein} with 2 billion CFU Bacillus coagulans Unique IS-2 (supplemental group) or 20 g of whey protein powder and lactose instead of Bacillus coagulans (placebo group) once daily for 60 days with a controlled resistance exercise protocol. The whey protein concentrate (WPC-80) given to both groups had a lactose content of 6.8%. Plasma-free amino acids (PFAAs) were determined at baseline, at 30 and 60 days of supplementation. Muscle strength, hypertrophy, VO2 max, and body composition, and other biochemical parameters were assessed at baseline and end line.
resultsA positive effect of probiotic Bacillus coagulans Unique IS-2 supplementation was observed on protein absorption as evidenced by an increase in total PFAA by + 16.1% (p = 0.004). Branched chain amino acids (BCAA) comprising isoleucine (p = 0.016), leucine (p = 0.001), and valine (p = 0.002) were increased by + 33.1% in ITT analysis as compared to placebo after 60 days. At 30 days an increase in isoleucine by + 35% (p = 0.113), leucine by + 43% (p = 0.032), and valine by + 32% (p = 0.017) was observed in ITT analysis. Probiotic effect was shown on exercise performance as evidenced by an increase in one RM of leg press and vertical jump power by + 16.61% (p = 0.024) and + 7.86% (p = 0.007), respectively.
conclusionSignificantly increased absorption of BCAA with supplementation of B. coagulans Unique IS-2 along with whey protein and improvement in leg press and vertical jump power was noted indicating the positive effect of the probiotic on muscle power in the lower body. TRIAL REGISTRATION NUMBER: CTRI/2017/03/008117; Date:16.03.2017.
Indexed as
Identifiers
35249118What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.