ArticleSchizophrenia (Heidelberg, Germany)2022
Effects of COVID-19-related stress and fear on depression in schizophrenia patients and the general population.
Article in Schizophrenia (Heidelberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Analysis of COVID-19-Related Influencing Variables and Post-Traumatic Growth Differences Depending on the Type of Depressive Symptoms Using Latent Profile Analysis.Psychiatry investigation · 2026Article
- Neurobiology of COVID-19-Associated Psychosis/Schizophrenia: Implication of Epidermal Growth Factor Receptor Signaling.Neuropsychopharmacology reports · 2025Review
- Influence of illness perception on depression and anxiety in individuals with schizophrenia during the COVID-19 pandemic.Frontiers in public health · 2025Article
- Predictors of the Fear of COVID-19 in Individuals with Schizophrenia: a Prospective Study.International journal of medical sciences · 2025Article
- COVID-19 experience of people with severe mental health conditions and families in South Africa.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2024Article
- Depression and stress levels in patients with different psychiatric disorders during concurrent early-phase COVID-19 pandemic and earthquake in Croatia.BMC psychiatry · 2023Article
- Psychological and Personality Characteristics Associated With COVID-19 Vaccination Behavior in Korean General Population.Journal of Korean medical science · 2023Article
- COVID-19 related risk factors and their association with non-syndromic orofacial clefts in five Arab countries: a case-control study.BMC oral health · 2023Article
- Prevalence, correlates, and network analysis of depression and its associated quality of life among ophthalmology nurses during the COVID-19 pandemic.Frontiers in psychology · 2023Article
- COVID-19 vaccine acceptance and related behavioral and psychological characteristics in individuals with mental disorders in Korea.Frontiers in psychiatry · 2023Article
- Predictors of COVID-19 Stress and COVID-19 Vaccination Acceptance among Adolescents in Ghana.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 1 country.
Funding
Abstract
This study compared the coronavirus disease 2019 (COVID-19)-related stress, fear of infection, loneliness, and depression between patients with schizophrenia and the general population. A face-to-face survey was administered to 1340 patients with a schizophrenia spectrum disorder and online survey of the general population (n = 2000) was conducted. The information gathered included the level of COVID-19-related stress, fear of infection, the Patient Health Questionnaire-9 score, and the three-item UCLA Loneliness Scale score. Structural equation modeling revealed a significant effect of fear of COVID-19 infection on depression among the general population and on loneliness among patients with schizophrenia. Loneliness experienced during COVID-19 exacerbated depression in both groups. In the COVID-19-related stress-loneliness-depression pathway, the partial mediating effect of loneliness was significant in both groups. Conversely, in the COVID-19-related fear-loneliness-depression pathway, the full mediating effect of loneliness was only significant in patients with schizophrenia. In conclusion, the loneliness associated with COVID-19-related stress and fear of infection was an important factor influencing depression, and the impact was greater in patients with schizophrenia compared with the general population. Thus, different mental health intervention plans are needed for patients with schizophrenia during the COVID-19 pandemic. During the long-lasting COVID-19 pandemic, social support and provision of mental health services to prevent loneliness and consequent depression are required in patients with schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.