Evidence map›Paper›PMID 35248780›Full record

ArticleVascular pharmacology2022

Endothelial dysfunction in acute and long standing COVID-19: A prospective cohort study.

Evangelos Oikonomou, Nektarios Souvaliotis, Stamatios Lampsas, Gerasimos Siasos, Garyphallia Poulakou, Panagiotis Theofilis, Theodore G Papaioannou, Anna-Bettina Haidich, Georgia Tsaousi, Vasileios Ntousopoulos and 8 more

Registry-linked trialAbstract read
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In one paragraph

Article in Vascular pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07312409 (Does Taurine Supplementation Improve Vascular Function and Orthostatic Responses in Long COVID?), which is not on this map. Cited by 75 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07312409 recruitingnot on this mapstarted 2026, after this paper: background citation

Does Taurine Supplementation Improve Vascular Function and Orthostatic Responses in Long COVID?

Typeobservational_patient_registrySponsorYork UniversityRan2026 to 2027Enrolled30ConditionsLong COVID SyndromeArmsTaurine supplementation
3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Evangelos Oikonomou3rd Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Sotiria Chest Disease Hospital, Athens, Greece; 1st Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Hippokration General Hospital, Athens, Greece. Electronic address: boikono@med.uoa.gr.
Nektarios Souvaliotis3rd Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Sotiria Chest Disease Hospital, Athens, Greece.
Stamatios Lampsas3rd Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Sotiria Chest Disease Hospital, Athens, Greece.
Gerasimos Siasos3rd Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Sotiria Chest Disease Hospital, Athens, Greece; 1st Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Hippokration General Hospital, Athens, Greece.
Garyphallia Poulakou3rd Department of Medicine, Medical School, Sotiria Chest Disease Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Panagiotis Theofilis1st Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Hippokration General Hospital, Athens, Greece.
Theodore G Papaioannou1st Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Hippokration General Hospital, Athens, Greece.
Anna-Bettina HaidichDepartment of Hygiene, Social-Preventive Medicine and Medical Statistics, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Georgia TsaousiDepartment of Anesthesiology and ICU, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Vasileios Ntousopoulos3rd Department of Medicine, Medical School, Sotiria Chest Disease Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Vissaria Sakka3rd Department of Medicine, Medical School, Sotiria Chest Disease Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Georgios CharalambousEmergency Department, "Hippokration" General Hospital, Athens, Greece.
Vasiliki Rapti3rd Department of Medicine, Medical School, Sotiria Chest Disease Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Sylvia RaftopoulouIntensive Care Unit, Sotiria Chest Disease Hospital, Athens, Greece.
Konstantinos Syrigos3rd Department of Medicine, Medical School, Sotiria Chest Disease Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Costas Tsioufis1st Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Hippokration General Hospital, Athens, Greece.
Dimitris Tousoulis1st Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Hippokration General Hospital, Athens, Greece.
Manolis Vavuranakis3rd Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Sotiria Chest Disease Hospital, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronavirus disease-19 (COVID-19) is implicated by active endotheliitis, and cardiovascular morbidity. The long-COVID-19 syndrome implications in atherosclerosis have not been elucidated yet. We assessed the immediate, intermediate, and long-term effects of COVID-19 on endothelial function.

methodsIn this prospective cohort study, patients hospitalized for COVID-19 at the medical ward or Intensive Care Unit (ICU) were enrolled and followed up to 6 months post-hospital discharge. Medical history and laboratory examinations were performed while the endothelial function was assessed by brachial artery flow-mediated dilation (FMD). Comparison with propensity score-matched cohort (control group) was performed at the acute (upon hospital admission) and follow-up (1 and 6 months) stages.

resultsSeventy-three patients diagnosed with COVID-19 (37% admitted in ICU) were recruited. FMD was significantly (p < 0.001) impaired in the COVID-19 group (1.65 ± 2.31%) compared to the control (6.51 ± 2.91%). ICU-treated subjects presented significantly impaired (p = 0.001) FMD (0.48 ± 1.01%) compared to those treated in the medical ward (2.33 ± 2.57%). During hospitalization, FMD was inversely associated with Interleukin-6 and Troponin I (p < 0.05 for all). Although, a significant improvement in FMD was noted during the follow-up (acute: 1.75 ± 2.19% vs. 1 month: 4.23 ± 2.02%, vs. 6 months: 5.24 ± 1.62%; p = 0.001), FMD remained impaired compared to control (6.48 ± 3.08%) at 1 month (p < 0.001) and 6 months (p = 0.01) post-hospital discharge.

conclusionCOVID-19 patients develop a notable endothelial dysfunction, which is progressively improved over a 6-month follow-up but remains impaired compared to healthy controls subjects. Whether chronic dysregulation of endothelial function following COVID-19 could be accompanied by a residual risk for cardiovascular and thrombotic events merits further research.

Indexed as

COVID-19Cohort StudiesEndothelium, VascularHumansPost-Acute COVID-19 SyndromeProspective StudiesVasodilationCOVID-19Endothelial functionEndotheliumFlow-mediated dilation

Identifiers

PMID35248780
PMCPMC8893931

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.