Evidence map›Paper›PMID 35248614›Full record

ArticleAntiviral research2022

An acyclic phosphonate prodrug of HPMPC is effective against VZV in skin organ culture and mice.

M G Lloyd, D Liu, J Lyu, J Fan, J M Overhulse, B A Kashemirov, M N Prichard, C E McKenna, J F Moffat

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antiviral research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Prodrug Strategies for the Development of β-l-5-((Journal of medicinal chemistry · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

M G LloydSUNY Upstate Medical University, Dept. of Microbiology & Immunology, Syracuse, NY, USA.
D LiuSUNY Upstate Medical University, Dept. of Microbiology & Immunology, Syracuse, NY, USA.
J LyuUniversity of Southern California, Dept. of Chemistry, Los Angeles, CA, USA.
J FanUniversity of Southern California, Dept. of Chemistry, Los Angeles, CA, USA.
J M OverhulseUniversity of Southern California, Dept. of Chemistry, Los Angeles, CA, USA.
B A KashemirovUniversity of Southern California, Dept. of Chemistry, Los Angeles, CA, USA.
M N PrichardUniversity of Alabama School of Medicine, Dept. of Pediatrics - Infectious Disease, Birmingham, AL, USA.
C E McKennaUniversity of Southern California, Dept. of Chemistry, Los Angeles, CA, USA.
J F MoffatSUNY Upstate Medical University, Dept. of Microbiology & Immunology, Syracuse, NY, USA. Electronic address: moffatj@upstate.edu.
University of Southern California · USSUNY Upstate Medical University · USUniversity of Alabama at Birmingham · US

Funding

Small Molecule Inhibitors Targeting AdenovirusR01AI135122 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCKENNA, CHARLES E · 2019 to 2023
$3.0M
CBI: Chemistry Biology InterfaceT32GM118289 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FORSBURG, SUSAN L · 2016 to 2020
$1.2M
Mechanistic Approaches to Inhibition of Emerging DNA VirusesR21AI130927 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRITT, WILLIAM JARVIS, MCKENNA, CHARLES E · 2018 to 2019
$454k
NIAID NIH HHS R01 AI135122NIAID NIH HHS R21 AI130927NIGMS NIH HHS T32 GM118289
6 · The paper itself

Abstract

Varicella zoster virus (VZV) causes chicken pox and shingles and is prevalent worldwide. Acyclovir and penciclovir (and its prodrugs) are first-line treatments for VZV infections, but they are not highly potent against VZV and resistance may arise in immunocompromised people on long-term therapy. HPMPC (cidofovir) is active against VZV, but cidofovir is not approved for treating VZV diseases, is nephrotoxic, and is not orally bioavailable. Here, we present the synthesis and evaluation of USC-373, a phosphonate prodrug of HPMPC with activity against VZV and other DNA viruses. In cultured fibroblasts, it was potent against VZV Ellen laboratory strain and was not overtly toxic, with EC

Indexed as

OrganophosphonatesProdrugsAcyclovirAnimalsAntiviral AgentsCidofovirHerpesvirus 3, HumanHumansMiceOrgan Culture TechniquesViral Regulatory and Accessory ProteinsAcyclovirAntiviral AgentsCidofovirORF57 protein, human herpesvirus 8OrganophosphonatesProdrugsViral Regulatory and Accessory ProteinsAntiviralNucleoside analogNuSkin humanized mousePhosphonate prodrugSkin organ cultureVaricella zoster virus

Identifiers

PMID35248614
PMCPMC12911940
OpenAlexW4220877791

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.