ArticleThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2022
Longitudinal Evidence of a Vicious Cycle Between Nucleus Accumbens Microstructure and Childhood Weight Gain.
Article in The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Weight gain and brain development in the ABCD study cohort: A decade of insight and the road ahead.Developmental cognitive neuroscience · 2026Review
- The ABCD Study at 10: The NIH perspective on progress, impact, and the road ahead.Developmental cognitive neuroscience · 2026Article
- Nonlinear associations between body mass index and brain microstructure across adolescence in the ABCD Study.bioRxiv : the preprint server for biology · 2026Article
- Brain Microstructure and Obesity Risk in Early Childhood: Insights from Restriction Spectrum Imaging.bioRxiv : the preprint server for biology · 2025Article
- Single-Nucleus Transcriptomics of the Nucleus Accumbens Reveals Cell-Type-Specific Dysregulation in Adolescent Macaques with Depressive-Like Behaviors.Neuroscience bulletin · 2025Article
- Distinct Patterns of Weight Gain, Age, and Subcortical Microstructure in Early Adolescence.JAMA network open · 2025Observational
- Smaller Subcortical Volume in Reward Processing Regions Precedes Weight Gain in Youth With High Financial Adversity: Findings From the Adolescent Brain Cognitive Development Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025Article
- Longitudinal analysis of the ABCD® study.Developmental cognitive neuroscience · 2025Review
- Delay discounting and nucleus accumbens functional connectivity are related to weight status in adolescents from the ABCD study.Pediatric obesity · 2025Article
- Ultra-processed food consumption affects structural integrity of feeding-related brain regions independent of and via adiposity.npj metabolic health and disease · 2025Article
- Breastfeeding duration and brain-body development in 9-10-year-olds: modulating effect of socioeconomic levels.Pediatric research · 2025Article
- Smaller subcortical volume relates to greater weight gain in girls with initially healthy weight.Obesity (Silver Spring, Md.) · 2024Article
- FTO variation and early frontostriatal brain development in children.Obesity (Silver Spring, Md.) · 2024Article
- Associations among prenatal exposure to gestational diabetes mellitus, brain structure, and child adiposity markers.Obesity (Silver Spring, Md.) · 2023Article
- Variation in executive function relates to BMI increases in youth who were initially of a healthy weight in the ABCD Study.Obesity (Silver Spring, Md.) · 2023Article
- Heightened sensitivity to high-calorie foods in children at risk for obesity: insights from behavior, neuroimaging, and genetics.Brain imaging and behavior · 2023Article
- Excess BMI in early adolescence adversely impacts maturating functional circuits supporting high-level cognition and their structural correlates.International journal of obesity (2005) · 2023Article
- Associations Between Socioeconomic Status, Obesity, Cognition, and White Matter Microstructure in Children.JAMA network open · 2023Article
- Associations between socioeconomic status and white matter microstructure in children: indirect effects via obesity and cognition.medRxiv : the preprint server for health sciences · 2023Article
- Childhood obesity is linked to putative neuroinflammation in brain white matter, hypothalamus, and striatum.Cerebral cortex communications · 2023Article
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Authors and funding
8 authors.
Funding
Abstract
purposePediatric obesity is a growing public health concern. Previous work has observed diet to impact nucleus accumbens (NAcc) inflammation in rodents, measured by the reactive proliferation of glial cells. Recent work in humans has demonstrated a relationship between NAcc cell density-a proxy for neuroinflammation-and weight gain in youth; however, the directionality of this relationship in the developing brain and association with diet remains unknown.
methodsWaist circumference (WC) and NAcc cell density were collected in a large cohort of children (n > 2,000) participating in the Adolescent Brain Cognitive Development (ABCD) Study (release 3.0) at baseline (9-10 y) and at a Year 2 follow-up (11-12 y). Latent change score modeling (LCSM) was used to disentangle contributions of baseline measures to two-year changes in WC percentile and NAcc cellularity. In addition, the role of NAcc cellularity in mediating the relationship between diet and WC percentile was assessed using dietary intake data collected at Year 2.
resultsLCSM indicates that baseline WC percentile influences change in NAcc cellularity and that baseline NAcc cell density influences change in WC percentile. NAcc cellularity was significantly associated with WC percentile at Year 2 and mediated the relationship between dietary fat consumption and WC percentile.
conclusionsThese results implicate a vicious cycle whereby NAcc cell density biases longitudinal changes in WC percentile and vice versa. Moreover, NAcc cell density may mediate the relationship between diet and weight gain in youth. These findings suggest that diet-induced inflammation of reward circuitry may lead to behavioral changes that further contribute to weight gain.
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