Evidence map›Paper›PMID 35248205›Full record

ReviewProgress in brain research2022

Neuromodulation of cognition in Parkinson's disease.

Rachel C Cole, Derrick N Okine, Brooke E Yeager, Nandakumar S Narayanan

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Progress in brain research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06984757 (Mid-frontal Delta/Theta and Cognitive Control), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
20.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06984757 naenrolling by invitationnot on this map

Mid-frontal Delta/Theta and Cognitive Control

TypeinterventionalSponsorNandakumar NarayananRan2017 to 2029Enrolled635ConditionsParkinson&Amp, Amp, #39, s Disease (PD)ArmsDeep-brain Stimulation, Transcranial Magnetic Stimulation, Transcranial Alternating Current Stimulation
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Frontiers in neuroscience · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rachel C ColeDepartment of Neurology, University of Iowa, Iowa City, IA, United States.
Derrick N OkineDepartment of Neurology, University of Iowa, Iowa City, IA, United States.
Brooke E YeagerDepartment of Neurology, University of Iowa, Iowa City, IA, United States.
Nandakumar S NarayananDepartment of Neurology, University of Iowa, Iowa City, IA, United States. Electronic address: nandakumar-narayanan@uiowa.edu.
University of Iowa · US

Funding

Mid-frontal delta/theta rhythms and cognitive control in PDR01NS100849 · NINDS · UNIVERSITY OF IOWA · PI JAMES F CAVANAGH, Nandakumar Narayanan · 2017 to 2026
$3.6M
The Administrative Core of Prefrontal Cortex, Cognition, and Speech Symptoms in Parkinson’s disease (PRECIS-PD)P20NS123151 · NINDS · UNIVERSITY OF IOWA · PI ALDRIDGE, GEORGINA · 2021 to 2022
$890k
Frontal theta as a mechanism of aging-related differences in cognitive controlF32AG069445 · NIA · UNIVERSITY OF IOWA · PI COLE, RACHEL AMELIA CLARK · 2020 to 2022
$171k
NIA NIH HHS F32 AG069445NINDS NIH HHS P20 NS123151NINDS NIH HHS R01 NS100849
6 · The paper itself

Abstract

Neuromodulation is a widely used treatment for motor symptoms of Parkinson's disease (PD). It can be a highly effective treatment as a result of knowledge of circuit dysfunction associated with motor symptoms in PD. However, the mechanisms underlying cognitive symptoms of PD are less well-known, and the effects of neuromodulation on these symptoms are less consistent. Nonetheless, neuromodulation provides a unique opportunity to modulate motor and cognitive circuits while minimizing off-target side effects. We review the modalities of neuromodulation used in PD and the potential implications for cognitive symptoms. There have been some encouraging findings with both invasive and noninvasive modalities of neuromodulation, and there are promising advances being made in the field of therapeutic neuromodulation. Substantial work is needed to determine which modulation targets are most effective for the different types of cognitive deficits of PD.

Indexed as

Cognitive DysfunctionDeep Brain StimulationParkinson DiseaseTranscranial Direct Current StimulationCognitionHumansTranscranial Magnetic StimulationTreatment OutcomeBasal gangliaDeep brain stimulationMovement disordersNonmotor symptomsPrefrontal cortexTranscranial alternating current stimulationTranscranial direct current stimulationTranscranial magnetic stimulation

Identifiers

PMID35248205
PMCPMC9199111
OpenAlexW4211152171

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.