ArticleBMC musculoskeletal disorders2022
Bidirectional association between knee osteoarthritis and depressive symptoms: evidence from a nationwide population-based cohort.
Article in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Re-examining the pain-depression vicious cycle in knee osteoarthritis: a random-intercept cross-lagged panel analysis.BMC musculoskeletal disorders · 2026Article
- Socioeconomic burden of osteoarthritis in Sub-Saharan Africa and the determinants of healthcare inequities: a scoping review protocol.BMJ open · 2026Article
- Brain-bone axis dysregulation: Biological code underlying the bidirectional association between depression and musculoskeletal disorders.Journal of orthopaedic translation · 2026Review
- Exploring risk factors for comorbid depression in osteoarthritis: a scoping review protocol.BMJ open · 2025Article
- The severity of depressive symptoms as a mediator in the sleep-osteoarthritis risk pathway: insights from the ELSA cohort.Frontiers in nutrition · 2025Article
- Gender differences in pre-surgical hip arthroplasty patients.Frontiers in global women's health · 2025Article
- Random Forest Regression May Become the Optimal Regression Model for Osteoarthritis of the Knee in Elderly, in the Context of Embodied Cognition and Psychosomatic Medicine.Journal of multidisciplinary healthcare · 2025Article
- Association of improvement and worsening of depressive symptoms with arthritis.BMC geriatrics · 2024Article
- Allied health professionals' experiences and views towards improving musculoskeletal services in the UK for patients with musculoskeletal and co-existing mental health conditions: a qualitative study.BMC musculoskeletal disorders · 2024Article
- Causal relationship between modifiable risk factors and knee osteoarthritis: a Mendelian randomization study.Frontiers in medicine · 2024Article
- Healthy and Osteoarthritis-Affected Joints Facing the Cellular Crosstalk.International journal of molecular sciences · 2023Review
- Factors Affecting Physical Activity of People with Knee Osteoarthritis in Southern Taiwan: A Multiple Logistic Regression Analysis.International journal of clinical practice · 2022Article
- Ecological momentary assessment for symptom monitoring among people with knee osteoarthritis: A scoping review.Digital healthReview
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth knee osteoarthritis (KOA) and depressive symptoms (DS) are major public health issues affecting the quality of life. This study aimed to examine the association between KOA and DS.
methodsData were gathered from the China Health and Retirement Longitudinal Study in 2011-2015 which surveyed middle-aged to elderly individuals and their spouses in 28 provinces in China. An adjusted Cox proportional hazards regression model was used to estimate hazard ratios (HRs).
resultsThe analysis for baseline KOA and the subsequent risk of DS was based on 2582 participants without baseline DS. During the follow-up, KOA patients were more likely to have DS than non-KOA participants (adjusted HR = 1.38: 95% CI = 1.23 to 1.83). The analysis for baseline DS and the subsequent risk of KOA was based on 4293 participants without baseline KOA, those with DS were more likely to develop KOA than non-DS participants (adjusted HR = 1.51: 95% CI = 1.26 to 1.81). Subgroup analysis showed sex and age had no significant moderating effect on the KOA-DS association.
conclusionsOur results provide evidence that the association between KOA and DS is bidirectional. Therefore, primary prevention and management of KOA and DS should consider this relationship.
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