ArticleBMC geriatrics2022
Age is the main determinant of COVID-19 related in-hospital mortality with minimal impact of pre-existing comorbidities, a retrospective cohort study.
Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04325412 (Cardiac complicAtions in Patients With SARS Corona vIrus 2 regisTrY), which is not on this map. Cited by 44 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cardiac complicAtions in Patients With SARS Corona vIrus 2 regisTrY
Who cites it
44 citing papers in PubMed, 69 citations in OpenAlex.
- Neuropsychiatric Involvement in Hospitalized COVID-19 Is Embedded in Multi-Organ Disease: A Retrospective Five-Axis Record-Derived Phenotype Atlas with Renal-Urinary Prognostic Dominance.Pathogens (Basel, Switzerland) · 2026Article
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- Age, sex and seasonal differences in COVID-19 viral load: a Lebanese cross-sectional study.BMC infectious diseases · 2025Article
- COVID-19 mortality among people living with HIV/AIDS in Brazil: a multilevel analysis.AIDS research and therapy · 2025Article
- Pain Complaints and Intubation Risk in COVID-19 Patients: A Retrospective Cross-Sectional Analysis.Cureus · 2025Article
- Charlson comorbidity index has no incremental value for mortality risk prediction in nursing home residents with COVID-19 disease.BMC geriatrics · 2025Observational
- Effects of the COVID-19 Pandemic on the Performance of Marathon Runners.Translational sports medicine · 2025Article
- Assessing the impact of Delta and Omicron in German intensive care units: a retrospective, nationwide multistate analysis.BMC health services research · 2024Article
- COVID-19 Vaccination Coverage and Factors Associated With Vaccine Uptake Among People With HIV.JAMA network open · 2024Article
- Early Outcomes of the Surgical Treatment of Non-traumatic Massive Pericardial Effusion in the University of the Philippines - Philippine General Hospital COVID-19 Referral Center.Acta medica Philippina · 2024Article
- Comparison of clinical characteristics and outcomes between COVID-19 survivors and non-survivors: a retrospective observational study.Wellcome open research · 2024Article
- Prediction of COVID-19 in-hospital mortality in older patients using artificial intelligence: a multicenter study.Frontiers in aging · 2024Article
- Effectiveness of regdanvimab on mortality in COVID-19 infected patients on hemodialysis.Kidney research and clinical practice · 2024Article
- Risk factors for COVID-19 mortality in hospitalized patients in Bolivia.IJID regions · 2023Article
- Unlocking the WHO's Age-Friendly Healthcare Principles: Portugal's Quest and Recommendations.International journal of environmental research and public health · 2023Article
- The Association of Endothelin-1 with Early and Long-Term Mortality in COVID-19.Journal of personalized medicine · 2023Article
- Direct impact of 2 years of COVID-19 on chronic disease patients: a population-based study in a large hard-hit Italian region.BMJ open · 2023Article
- Effectiveness and Safety of Remdesivir in Treating Hospitalised Patients with COVID-19: A Propensity Score Analysis of Real-Life Data from a Monocentric Observational Study in Times of Health Emergency.Clinical drug investigation · 2023Observational
- Age-related changes in plasma biomarkers and their association with mortality in COVID-19.The European respiratory journal · 2023Article
- Comparative assessment of SARS CoV2-associated mortalities in 3 COVID waves and related risk factors: The South Kashmir's experience.Journal of family medicine and primary care · 2023Article
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Authors and funding
16 authors at 9 institutions in 3 countries.
Funding
Abstract
backgroundAge and comorbidities increase COVID-19 related in-hospital mortality risk, but the extent by which comorbidities mediate the impact of age remains unknown.
methodsIn this multicenter retrospective cohort study with data from 45 Dutch hospitals, 4806 proven COVID-19 patients hospitalized in Dutch hospitals (between February and July 2020) from the CAPACITY-COVID registry were included (age 69[58-77]years, 64% men). The primary outcome was defined as a combination of in-hospital mortality or discharge with palliative care. Logistic regression analysis was performed to analyze the associations between sex, age, and comorbidities with the primary outcome. The effect of comorbidities on the relation of age with the primary outcome was evaluated using mediation analysis.
resultsIn-hospital COVID-19 related mortality occurred in 1108 (23%) patients, 836 (76%) were aged ≥70 years (70+). Both age 70+ and female sex were univariably associated with outcome (odds ratio [OR]4.68, 95%confidence interval [4.02-5.45], OR0.68[0.59-0.79], respectively;both p< 0.001). All comorbidities were univariably associated with outcome (p<0.001), and all but dyslipidemia remained significant after adjustment for age70+ and sex. The impact of comorbidities was attenuated after age-spline adjustment, only leaving female sex, diabetes mellitus (DM), chronic kidney disease (CKD), and chronic pulmonary obstructive disease (COPD) significantly associated (female OR0.65[0.55-0.75], DM OR1.47[1.26-1.72], CKD OR1.61[1.32-1.97], COPD OR1.30[1.07-1.59]). Pre-existing comorbidities in older patients negligibly (<6% in all comorbidities) mediated the association between higher age and outcome.
conclusionsAge is the main determinant of COVID-19 related in-hospital mortality, with negligible mediation effect of pre-existing comorbidities.
trial registrationCAPACITY-COVID ( NCT04325412 ).
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