Trial reportBMC gastroenterology2022
Administration of probiotics to healthy volunteers: effects on reactivity of intestinal mucosa and systemic leukocytes.
Trial report in BMC gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01534572 (Significance of Synbiotics on Inflammation and Proliferation of Colonic Mucosa), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Significance of Synbiotics on Inflammation and Proliferation of Colonic Mucosa
Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Oral intake ofNutrients · 2023Trial
- Article
- Study of the Effect of Synbiotic Diet on Haematological and Oxidative Indexes Changes in Male Dogs.Veterinary medicine and science · 2025Article
- Probiotic supplementation for optimizing athletic performance: current evidence and future perspectives for microbiome-based strategies.Frontiers in nutrition · 2025Review
- Exploring the In Vitro Antibacterial Potential of Specific Probiotic Strains against Oral Pathogens.Microorganisms · 2024Article
- Effects of three different probiotics of Tibetan sheep origin and their complex probiotics on intestinal damage, immunity, and immune signaling pathways of mice infected withFrontiers in microbiology · 2023Article
- A Review of Immunomodulatory Reprogramming by Probiotics in Combating Chronic and Acute Diabetic Foot Ulcers (DFUs).Pharmaceutics · 2022Review
- Effects of bifidobacterium lactis bb12 probiotic consumption on streptococcus mutans levels: a systematic review of randomized clinical trials.Revista cientifica odontologica (Universidad Cientifica del Sur)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOral administration of health-promoting bacteria is increasingly used in clinical practise. These bacteria have anti-inflammatory characteristics and modulate the immune system without major reported side effects. The mechanisms of action are not yet fully defined. Our aim was to study systemic effects of probiotics by measurements of leukocytes as well as local effects on rectal mucosal biopsies after adding a standardized inflammatory stimulus in vitro.
methodsFourteen healthy subjects were randomized to receive 10
resultsComposition of the intestinal microbiota was not changed. Systemic leukocytes decreased after administration of CURE21 (P<0.05) and Lp299 (P<0.01). Levels of the pro-inflammatory cytokine IL-6 in rectal mucosa after stimulation with TNF-α were attenuated after ingestion of Lp299. No effect was seen with CURE21.
conclusionsAdministration of these probiotic strains to healthy humans show both a systemic and local reduction of inflammatory response by lowering leukocyte counts, and for Lp299 IL-6 levels in rectal mucosa. Probiotics may play an important role in the reduction of inflammatory responses expected after trauma during surgery or after pelvic irradiation. Trial registration Clinical Trials, registration number NCT01534572, retrospectively registered ( http://www.clinicaltrials.gov ).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.