Evidence map›Paper›PMID 35247969›Full record

ArticleBMC nephrology2022

Late antibody-mediated rejection in a kidney transplant recipient: COVID 19 induced?

Nicole Nourié, Hussein Nassereddine, Sarah Mouawad, Louaa Chebbou, Rita Ghaleb, Fatmeh Abbas, Hiba Azar

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Nicole NouriéNephrology Department, Saint Joseph University, Hôtel-Dieu de France, Beirut, Lebanon. nicolenourie@yahoo.com.
Hussein NassereddinePathology Department, Saint Joseph University, Hôtel-Dieu de France, Beirut, Lebanon.
Sarah MouawadNephrology Department, Saint Joseph University, Hôtel-Dieu de France, Beirut, Lebanon.
Louaa ChebbouNephrology Department, Saint Joseph University, Hôtel-Dieu de France, Beirut, Lebanon.
Rita GhalebNephrology Department, Saint Joseph University, Hôtel-Dieu de France, Beirut, Lebanon.
Fatmeh AbbasDepartment of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Hiba AzarNephrology Department, Saint Joseph University, Hôtel-Dieu de France, Beirut, Lebanon.
Saint Joseph University · LBAmerican University of Beirut Medical Center · LBHôtel-Dieu de France · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntibody-mediated rejection (AMR) was described in kidney transplant patients after viral infections, such as the cytomegalovirus. Very few cases were recently reported after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, probably in the context of lowering of immunosuppressive therapy. To date, no direct immunological link was proved to explain a connection between the coronavirus disease 19 (COVID-19) infection and antibody-mediated rejection (AMR) if it exists. CASE PRESENTATION: Here we try to find this association by presenting the case of a low immunological risk patient who presented, six years post-transplant, with c4d negative antibody mediated rejection due to an anti-HLA-C17 de novo donor specific antibody (DSA) after contracting the coronavirus disease 19. The HLA-Cw17 activated the antibody-dependent cell-mediated cytotoxicity via the KIR2DS1 positive NK cells. DISCUSSION AND

conclusionsThis case report may prove a direct role for COVID-19 infection in AMRs in the kidney transplant recipients, leading us to closely monitor kidney transplant recipients, especially if they have "at-risk" donor antigens.

Indexed as

Kidney TransplantationAntibodiesCOVID-19Graft RejectionHumansMaleMiddle AgedTime FactorsAntibodiesAntibody mediated rejectionCase reportCOVID 19Natural killers

Identifiers

PMID35247969
PMCPMC8897769
OpenAlexW4220822757

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.