Evidence map›Paper›PMID 35247961›Full record

ArticleBMC genomics2022

Genome-wide recombination map construction from single sperm sequencing in cattle.

Liu Yang, Yahui Gao, Mingxun Li, Ki-Eun Park, Shuli Liu, Xiaolong Kang, Mei Liu, Adam Oswalt, Lingzhao Fang, Bhanu P Telugu and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 13 institutions in 4 countries.

Liu Yang *Animal Genomics and Improvement Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Beltsville, MD, 20705, USA.
Yahui Gao *Animal Genomics and Improvement Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Beltsville, MD, 20705, USA.
Mingxun LiCollege of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Ki-Eun ParkDepartment of Animal and Avian Sciences, University of Maryland, College Park, MD, 20742, USA.
Shuli LiuAnimal Genomics and Improvement Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Beltsville, MD, 20705, USA.
Xiaolong KangCollege of Agriculture, Ningxia University, Yinchuan, 750021, China.
Mei LiuAnimal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128, China.
Adam OswaltSelect Sires Inc, 11740 U.S. 42 North, Plain City, OH, 43064, USA.
Lingzhao FangThe Roslin Institute, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Midlothian, EH25 9RG, UK.
Bhanu P TeluguDepartment of Animal and Avian Sciences, University of Maryland, College Park, MD, 20742, USA.
Charles G SattlerSelect Sires Inc, 11740 U.S. 42 North, Plain City, OH, 43064, USA.
Cong-Jun LiAnimal Genomics and Improvement Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Beltsville, MD, 20705, USA.
John B ColeAnimal Genomics and Improvement Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Beltsville, MD, 20705, USA.
Eyal SeroussiAgricultural Research Organization (ARO), Volcani Center, Institute of Animal Science, P.O.B 15159, HaMaccabim Road, 7528809, Rishon LeTsiyon, Israel.
Lingyang XuInnovation Team of Cattle Genetic Breeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
Lv YangKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education & College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Yang ZhouKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education & College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.
Li LiCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China.
Hongping ZhangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China.
Benjamin D RosenAnimal Genomics and Improvement Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Beltsville, MD, 20705, USA.
Curtis P Van TassellAnimal Genomics and Improvement Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Beltsville, MD, 20705, USA.
Li MaDepartment of Animal and Avian Sciences, University of Maryland, College Park, MD, 20742, USA. lima@umd.edu.
George E LiuAnimal Genomics and Improvement Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Beltsville, MD, 20705, USA. George.Liu@usda.gov.
Beltsville Agricultural Research Center · USSichuan Agricultural University · CNUniversity of Maryland, College Park · USAgricultural Research Organization · ILAgricultural Research Service · USChina Agricultural University · CNHuazhong Agricultural University · CNHunan Agricultural University · CNInstitute of Animal Sciences · CNNingxia University · CNUniversity of Edinburgh · GBUniversity of Missouri · USYangzhou University · CN

Funding

National Institute of Food and Agriculture 2016-67015-24886National Institute of Food and Agriculture 2020-67015-31398United States - Israel Binational Agricultural Research and Development Fund US-4997-17
6 · The paper itself

Abstract

backgroundMeiotic recombination is one of the important phenomena contributing to gamete genome diversity. However, except for human and a few model organisms, it is not well studied in livestock, including cattle.

resultsTo investigate their distributions in the cattle sperm genome, we sequenced 143 single sperms from two Holstein bulls. We mapped meiotic recombination events at high resolution based on phased heterozygous single nucleotide polymorphism (SNP). In the absence of evolutionary selection pressure in fertilization and survival, recombination events in sperm are enriched near distal chromosomal ends, revealing that such a pattern is intrinsic to the molecular mechanism of meiosis. Furthermore, we further validated these findings in single sperms with results derived from sequencing its family trio of diploid genomes and our previous studies of recombination in cattle.

conclusionsTo our knowledge, this is the first large-scale single sperm whole-genome sequencing effort in livestock, which provided useful information for future studies of recombination, genome instability, and male infertility.

Indexed as

MeiosisRecombination, GeneticAnimalsCattleChromosome MappingMalePolymorphism, Single NucleotideSequence Analysis, DNASpermatozoaCattleRecombinationSequencingSingle sperm

Identifiers

PMID35247961
PMCPMC8898482
OpenAlexW4220949328

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.