Evidence map›Paper›PMID 35247654›Full record

ReviewJournal of autoimmunity2022

Diffuse cutaneous systemic sclerosis following SARS-Co V-2 vaccination.

Alice Cole, Rhys Thomas, Nina Goldman, Kevin Howell, Kuntal Chakravarty, Christopher P Denton, Voon H Ong

Open access · greenAbstract readCase ReportsReview
In one paragraph

Review in Journal of autoimmunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Alice ColeUCL Centre for Rheumatology and Connective Tissue Diseases, London, UK.
Rhys ThomasRoyal Free London NHS Foundation Trust, London, UK.
Nina GoldmanUCL Centre for Rheumatology and Connective Tissue Diseases, London, UK.
Kevin HowellRoyal Free London NHS Foundation Trust, London, UK.
Kuntal ChakravartyRoyal Free London NHS Foundation Trust, London, UK.
Christopher P DentonUCL Centre for Rheumatology and Connective Tissue Diseases, London, UK.
Voon H OngUCL Centre for Rheumatology and Connective Tissue Diseases, London, UK. Electronic address: v.ong@ucl.ac.uk.
Royal Free London NHS Foundation Trust · GBTissue Gene (United States) · USUCL Biomedical Research Centre · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The largest world-wide vaccination rollout ever is currently underway to tackle the covid-19 pandemic. We report a case of diffuse cutaneous systemic sclerosis (SSc) in a 70-year-old male with rapidly progressive skin thickening which developed two weeks after receiving the first dose of the ChAdOx1 nCOV-19 vaccine. As the onset of SSc skin was in close temporal proximity to the administration of the first dose vaccine with no other triggers, we suspected a possible adverse reaction to the ChAdOx1 nCOV-19 vaccine. We hypothesise that the recombinant adenoviral vector encoding the spike protein antigen of SARS-CoV-2 triggered an unexpected immune activation resulting in an atypical presentation of late-onset SSc, within the well-recognised ANA positive, ENA negative subgroup of patients.We review the possible mechanisms underlying autoimmunity when provoked by vaccination and other published rheumatological phenomenon occurring shortly after COVID vaccination.

Indexed as

COVID-19Scleroderma, DiffuseAgedChAdOx1 nCoV-19COVID-19 VaccinesHumansMalePandemicsSARS-CoV-2VaccinationChAdOx1 nCoV-19COVID-19 VaccinesAutoimmunityCapillaroscopySystemic sclerosisVaccine

Identifiers

PMID35247654
PMCPMC8888103
OpenAlexW4214919417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.