Evidence map›Paper›PMID 35247375›Full record

ReviewJournal of molecular and cellular cardiology2022

Multilayer control of cardiac electrophysiology by microRNAs.

Dandan Yang, Isabelle Deschênes, Ji-Dong Fu

Open access · greenAbstract readReview
In one paragraph

Review in Journal of molecular and cellular cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dandan YangThe Dorothy M. Davis Heart and Lung Research Institute, Frick Center for Heart Failure and Arrhythmia, Department of Physiology and Cell Biology, The Ohio State University, 333 W. 10(th) Avenue, Columbus, OH 43210, USA.
Isabelle DeschênesThe Dorothy M. Davis Heart and Lung Research Institute, Frick Center for Heart Failure and Arrhythmia, Department of Physiology and Cell Biology, The Ohio State University, 333 W. 10(th) Avenue, Columbus, OH 43210, USA.
Ji-Dong FuThe Dorothy M. Davis Heart and Lung Research Institute, Frick Center for Heart Failure and Arrhythmia, Department of Physiology and Cell Biology, The Ohio State University, 333 W. 10(th) Avenue, Columbus, OH 43210, USA. Electronic address: jidong.fu@osumc.edu.
The Ohio State University · US

Funding

Biophysical Modulation of Cardiac Ion Channels by MicroRNAR01HL139006 · NHLBI · OHIO STATE UNIVERSITY · PI Isabelle Deschenes, Jidong Fu · 2017 to 2026
$5.1M
Cardiac Ion Channel RegulationR01HL096962 · NHLBI · OHIO STATE UNIVERSITY · PI DESCHENES, ISABELLE, TSENG, GEA-NY · 2010 to 2021
$3.6M
Transcriptional Regulation of Ion Channels in Heart Failure and ArrhythmiasR01HL132520 · NHLBI · OHIO STATE UNIVERSITY · PI DESCHENES, ISABELLE · 2016 to 2019
$2.4M
NHLBI NIH HHS R01 HL096962NHLBI NIH HHS R01 HL132520NHLBI NIH HHS R01 HL139006
6 · The paper itself

Abstract

The electrophysiological properties of the heart include cardiac automaticity, excitation (i.e., depolarization and repolarization of action potential) of individual cardiomyocytes, and highly coordinated electrical propagation through the whole heart. An abnormality in any of these properties can cause arrhythmias. MicroRNAs (miRs) have been recognized as essential regulators of gene expression through the conventional RNA interference (RNAi) mechanism and are involved in a variety of biological events. Recent evidence has demonstrated that miRs regulate the electrophysiology of the heart through fine regulation by the conventional RNAi mechanism of the expression of ion channels, transporters, intracellular Ca

Indexed as

MicroRNAsArrhythmias, CardiacElectrophysiologic Techniques, CardiacHumansIon ChannelsMyocytes, CardiacIon ChannelsMicroRNAsArrhythmiaBiophysical modulationElectrophysiologymicroRNARNAi

Identifiers

PMID35247375
PMCPMC9035102
OpenAlexW4214821533

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.