Evidence map›Paper›PMID 35247136›Full record

ArticleNeuroinformatics2022

nGauge: Integrated and Extensible Neuron Morphology Analysis in Python.

Logan A Walker, Jennifer S Williams, Ye Li, Douglas H Roossien, Wei Jie Lee, Sylvia N Michki, Dawen Cai

Abstract read
In one paragraph

Article in Neuroinformatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Logan A Walker *Biophysics Program, University of Michigan LS&A, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-5378-3315
Jennifer S Williams *Electrical Engineering and Computer Science, University of Michigan Engineering, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3541-2756
Ye LiCell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-8647-384X
Douglas H RoossienDepartment of Biology, Ball State University, Muncie, IN, USA.ORCID http://orcid.org/0000-0003-1184-2919
Wei Jie LeeElectrical Engineering and Computer Science, University of Michigan Engineering, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7591-0234
Sylvia N MichkiBiophysics Program, University of Michigan LS&A, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-0403-0648
Dawen CaiBiophysics Program, University of Michigan LS&A, Ann Arbor, MI, USA. dwcai@umich.edu.ORCID http://orcid.org/0000-0003-4471-2061

Funding

Development of a scalable strategy for reconstructing cell-type determined connectome of the mammalian brainRF1MH124611 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAI, DAWEN, CUI, MENG · 2020 to 2020
$3.9M
Integrative labeling, imaging, and reconstruction tools for high-throughput inhibitory microconnectivity analysis in the mouse brainRF1MH123402 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAI, DAWEN, YAN, YAN · 2020 to 2020
$3.1M
NIMH NIH HHS RF1 MH123402NIMH NIH HHS RF1 MH124611
6 · The paper itself

Abstract

The study of neuron morphology requires robust and comprehensive methods to quantify the differences between neurons of different subtypes and animal species. Several software packages have been developed for the analysis of neuron tracing results stored in the standard SWC format. The packages, however, provide relatively simple quantifications and their non-extendable architecture prohibit their use for advanced data analysis and visualization. We developed nGauge, a Python toolkit to support the parsing and analysis of neuron morphology data. As an application programming interface (API), nGauge can be referenced by other popular open-source software to create custom informatics analysis pipelines and advanced visualizations. nGauge defines an extendable data structure that handles volumetric constructions (e.g. soma), in addition to the SWC linear reconstructions, while remaining lightweight. This greatly extends nGauge's data compatibility.

Indexed as

NeuronsSoftwareAnimalsCell BodyData AnalysisNeuron morphometricsNeuron reconstructionNeuron visualization

Identifiers

PMID35247136
PMCPMC9720862

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.