Evidence map›Paper›PMID 35247116›Full record

SynthesisInternational ophthalmology2022

An exploratory analysis of forme fruste keratoconus sensitivity diagnostic parameters.

Hui Zhang, Xue Zhang, Lin Hua, Lin Li, Lei Tian, Xinxin Zhang, Haixia Zhang

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in International ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hui ZhangSchool of Biomedical Engineering, Capital Medical University, Beijing, 100069, China.
Xue ZhangSchool of Biomedical Engineering, Capital Medical University, Beijing, 100069, China.
Lin HuaSchool of Biomedical Engineering, Capital Medical University, Beijing, 100069, China.
Lin LiSchool of Biomedical Engineering, Capital Medical University, Beijing, 100069, China.
Lei TianBeijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Xinxin ZhangSchool of Statistics, Capital University of Economics and Business, Beijing, 100070, China.
Haixia ZhangSchool of Biomedical Engineering, Capital Medical University, Beijing, 100069, China. Zhanghx@ccmu.edu.cn.ORCID http://orcid.org/0000-0001-5489-5987
Capital Medical University · CNBeijing Tongren Hospital · CN

Funding

National Natural Science Foundation of China 32171304
6 · The paper itself

Abstract

purposeTo secondary statistical analysis of the Pentacam or Corvis ST parameters from literatures, and to obtain more sensitive diagnostic parameters for clinical keratoconus (CKC) and forme fruste keratoconus (FFKC), respectively.

methodsThe parameters and the corresponding area of ROC curve (AUC) in previous studies were extracted and screened to obtain the database of CKC (Data-CKC) and FFKC (Data-FFKC), respectively. Two different importance evaluation methods (%IncMSE and IncNodePurity) of random forest were used to preliminary select the important parameters. Then, based on the partial dependency analysis, the sensitive diagnostic parameters that had promotion to the diagnostic performance were obtained. Data-FFKC was analyzed in the same way. Finally, a diagnostic test meta-analysis on the sensitive parameter of interest was conducted to verify the reliability of the above analysis methods.

resultsThere were 88 parameters with 766 records in Data-CKC, 57 parameters with 346 records in Data-FFKC. Based on two importance evaluation methods, 60 important parameters were obtained, of which 20 were further screened as sensitive parameters of keratoconus, and most of these parameters were related to the thinnest point of cornea. The stiffness parameter at first applanation (SPA1) was the only Corvis ST output parameter sensitive to FFKC except the Tomographic and Biomechanical Index and the Corvis Biomechanical Parameter (CBI). A total of 4 records were included in the meta-analysis of diagnostic tests on SPA1. The results showed that there was threshold effect, but no significant heterogeneity (I

conclusionsFor the diagnosis of FFKC, the sensitivity of SPA1 is not inferior to the well-known CBI, and may be the earliest Corvis ST output parameter to reflect the changes of corneal biomechanics during keratoconus progression. The elevation parameters based on the typical position of the thinnest point of corneal thickness are of great significance for the diagnosis of keratoconus.

Indexed as

KeratoconusBiomechanical PhenomenaCorneaCorneal TopographyHumansReproducibility of ResultsRetrospective StudiesROC CurveArea under ROC curve (AUC)Forme fruste keratoconusRandom forest regressionSensitive diagnostic parameters

Identifiers

PMID35247116
OpenAlexW4221132753

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.