Evidence map›Paper›PMID 35247012›Full record

ArticleCancer science2022

PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia-like features.

Katsuya Fukui, Miyuki Nomura, Kazuhiro Kishimoto, Nobuhiro Tanuma, Koreyuki Kurosawa, Kosuke Kanazawa, Hiroyuki Kato, Tomoki Sato, Shinji Miura, Koh Miura and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 1 country.

Katsuya FukuiDivision of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Japan.
Miyuki NomuraDivision of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Japan.
Kazuhiro KishimotoDivision of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Japan.
Nobuhiro TanumaDivision of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Japan.ORCID https://orcid.org/0000-0001-7914-1380
Koreyuki KurosawaDivision of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Japan.
Kosuke KanazawaDivision of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Japan.
Hiroyuki KatoDivision of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Japan.
Tomoki SatoLaboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan.
Shinji MiuraLaboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan.
Koh MiuraDivision of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Japan.
Ikuro SatoDivision of Pathology, Miyagi Cancer Center, Natori, Japan.
Hiroyuki TsujiDepartment of Head and Neck Surgery, Kanazawa Medical University, Kanazawa, Japan.
Yoji YamashitaDivision of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Japan.
Keiichi TamaiDivision of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori, Japan.ORCID https://orcid.org/0000-0003-0813-5885
Toshio WatanabeDepartment of Biological Science, Graduate School of Humanities and Sciences, Nara Women's University, Nara, Japan.
Jun YasudaDivision of Cancer Molecular Biology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Takuji TanakaResearch Center of Diagnostic Pathology, Gifu Municipal Hospital, Gifu, Japan.
Kennichi SatohDivision of Gastroenterology, Tohoku Medical Pharmaceutical University, Sendai, Japan.
Toru FurukawaDepartment of Investigative Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID https://orcid.org/0000-0002-1083-2324
Keiichi JinguDepartment of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hiroshi ShimaDivision of Cancer Chemotherapy, Miyagi Cancer Center Research Institute, Natori, Japan.ORCID https://orcid.org/0000-0002-0857-8929
Tohoku University · JPMiyagi Prefectural Hospital Organization · JPKanazawa University · JPUniversity of Shizuoka · JPGifu Municipal Hospital · JPNara Women's University · JPTohoku Medical and Pharmaceutical University · JP

Funding

Japan Society for the Promotion of Science 17K07187Japan Society for the Promotion of Science 19K18757Japan Society for the Promotion of Science 21K15425
6 · The paper itself

Abstract

To examine effects of PP6 gene (Ppp6c) deficiency on pancreatic tumor development, we developed pancreas-specific, tamoxifen-inducible Cre-mediated KP (KRAS(G12D) plus Trp53-deficient) mice (cKP mice) and crossed them with Ppp6c

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsAnimalsCachexiaCarcinogenesisHumansMiceMutationPhosphoprotein PhosphatasesProto-Oncogene Proteins p21(ras)KRAS protein, humanPhosphoprotein Phosphatasesprotein phosphatase 6Proto-Oncogene Proteins p21(ras)cachexiaIL-6K-raspancreatic ductal adenocarcinomaprotein phosphatase 6

Identifiers

PMID35247012
PMCPMC9128171
OpenAlexW4221079555

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.