Evidence map›Paper›PMID 35246669›Full record

ReviewNature reviews. Genetics2022

Sociotechnical safeguards for genomic data privacy.

Zhiyu Wan, James W Hazel, Ellen Wright Clayton, Yevgeniy Vorobeychik, Murat Kantarcioglu, Bradley A Malin

Erratum issuedAbstract readReview
In one paragraph

Review in Nature reviews. Genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 66 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Navigating data sharing in research.American journal of human genetics · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Zhiyu Wan *Center for Genetic Privacy and Identity in Community Settings, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-3752-5778
James W Hazel *Center for Genetic Privacy and Identity in Community Settings, Vanderbilt University Medical Center, Nashville, TN, USA.
Ellen Wright ClaytonCenter for Genetic Privacy and Identity in Community Settings, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-0308-4110
Yevgeniy VorobeychikDepartment of Computer Science and Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Murat KantarciogluDepartment of Computer Science, University of Texas at Dallas, Richardson, TX, USA.
Bradley A MalinCenter for Genetic Privacy and Identity in Community Settings, Vanderbilt University Medical Center, Nashville, TN, USA. b.malin@vumc.org.

Funding

Genetic Privacy and Identity in Community Settings - GetPreCiSeRM1HG009034 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CLAYTON, ELLEN WRIGHT, MALIN, BRADLEY A. · 2016 to 2024
$8.3M
A Risk Management Framework for Identifiability in Genomics ResearchR01HG006844 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MALIN, BRADLEY A. · 2012 to 2019
$2.4M
Technologies to Enable Privacy in Biomedical DatabanksR01LM009989 · NLM · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MALIN, BRADLEY A. · 2009 to 2014
$1.6M
NHGRI NIH HHS R01 HG006844NHGRI NIH HHS RM1 HG009034NLM NIH HHS R01 LM009989
6 · The paper itself

Abstract

Recent developments in a variety of sectors, including health care, research and the direct-to-consumer industry, have led to a dramatic increase in the amount of genomic data that are collected, used and shared. This state of affairs raises new and challenging concerns for personal privacy, both legally and technically. This Review appraises existing and emerging threats to genomic data privacy and discusses how well current legal frameworks and technical safeguards mitigate these concerns. It concludes with a discussion of remaining and emerging challenges and illustrates possible solutions that can balance protecting privacy and realizing the benefits that result from the sharing of genetic information.

Indexed as

GenomicsPrivacyGenome

Identifiers

PMID35246669
PMCPMC8896074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.