Evidence map›Paper›PMID 35246635›Full record

ArticleMolecular psychiatry2022

Highly unstable heterogeneous representations in VIP interneurons of the anterior cingulate cortex.

Connor Johnson, Lisa N Kretsge, William W Yen, Balaji Sriram, Alexandra O'Connor, Ruichen Sky Liu, Jessica C Jimenez, Rhushikesh A Phadke, Kelly K Wingfield, Charlotte Yeung and 11 more

Open access · greenAbstract read
In one paragraph

Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  8. Article
  9. Principles of nociceptive coding in the anterior cingulate cortex.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Using deep learning to study emotional behavior in rodent models.Frontiers in behavioral neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Connor Johnson *Neurobiology Section in the Department of Biology, Boston University, Boston, MA, USA.
Lisa N Kretsge *The Graduate Program for Neuroscience, Boston University, Boston, MA, USA.
William W Yen *Neurobiology Section in the Department of Biology, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3536-3122
Balaji SriramPraxis Precision Medicines, Inc., Boston, MA, USA.
Alexandra O'ConnorDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.
Ruichen Sky LiuMS in Statistical Practice Program, Boston University, Boston, MA, USA.
Jessica C JimenezDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Rhushikesh A PhadkeMolecular Biology, Cell Biology and Biochemistry Program, Boston University, Boston, MA, USA.
Kelly K WingfieldNeurophotonics Center, Boston University, Boston, MA, USA.
Charlotte YeungNeurobiology Section in the Department of Biology, Boston University, Boston, MA, USA.
Tushare J JinadasaNeurobiology Section in the Department of Biology, Boston University, Boston, MA, USA.
Thanh P H NguyenDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.
Eun Seon ChoNeurobiology Section in the Department of Biology, Boston University, Boston, MA, USA.
Erelle FuchsNeurobiology Section in the Department of Biology, Boston University, Boston, MA, USA.
Eli D SpevackNeurobiology Section in the Department of Biology, Boston University, Boston, MA, USA.
Berta Escude VelascoNeurobiology Section in the Department of Biology, Boston University, Boston, MA, USA.
Frances S HausmannNeurobiology Section in the Department of Biology, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1806-5625
Luke A FournierNeurobiology Section in the Department of Biology, Boston University, Boston, MA, USA.
Alison BrackMolecular Biology, Cell Biology and Biochemistry Program, Boston University, Boston, MA, USA.
Sarah MelzerDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6028-9764
Alberto Cruz-MartínNeurobiology Section in the Department of Biology, Boston University, Boston, MA, USA. martini.cruz@gmail.com.ORCID http://orcid.org/0000-0002-3271-7220
Boston University · USHoward Hughes Medical Institute · USPraxis (United States) · USUniversity of California, San Francisco · US

Funding

TRAINING IN BIOMOLECULAR PHARMACOLOGYT32GM008541 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FARB, DAVID H · 1997 to 2022
$5.2M
Functional heterogeneity of vasoactive intestinal peptide-expressing interneurons in the anterior cingulate cortex R01MH129732 · NIMH · UNIVERSITY OF COLORADO DENVER · PI Alberto Cruz-Martin · 2022 to 2026
$2.0M
NIGMS NIH HHS T32 GM008541NIMH NIH HHS R01 MH129732
6 · The paper itself

Abstract

A hallmark of the anterior cingulate cortex (ACC) is its functional heterogeneity. Functional and imaging studies revealed its importance in the encoding of anxiety-related and social stimuli, but it is unknown how microcircuits within the ACC encode these distinct stimuli. One type of inhibitory interneuron, which is positive for vasoactive intestinal peptide (VIP), is known to modulate the activity of pyramidal cells in local microcircuits, but it is unknown whether VIP cells in the ACC (VIP

Indexed as

Gyrus CinguliVasoactive Intestinal PeptideAnimalsInterneuronsMiceNeuronsPyramidal CellsVasoactive Intestinal Peptide

Identifiers

PMID35246635
PMCPMC11128891
OpenAlexW4220750672

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.