Evidence map›Paper›PMID 35246602›Full record

ArticleJournal of human hypertension2023

Integrated multi-month dispensing of antihypertensive and antiretroviral therapy to sustain hypertension and HIV control.

Isaac Derickk Kimera, Christabellah Namugenyi, Jeremy I Schwartz, Douglas Joseph Musimbaggo, Rebecca Ssenyonjo, Praise Atukunda, Gerald Mutungi, Frank Mugabe, Fortunate Ambangira, Mary Mbuliro and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of human hypertension, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Isaac Derickk KimeraMakerere University Joint AIDS Program, Kampala, Uganda. 74kimera@gmail.com.ORCID 0000-0003-4024-1872
Christabellah NamugenyiMakerere University Joint AIDS Program, Kampala, Uganda.
Jeremy I SchwartzSection of General Internal Medicine, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06511, USA.
Douglas Joseph MusimbaggoMakerere University Joint AIDS Program, Kampala, Uganda.
Rebecca SsenyonjoMakerere University Joint AIDS Program, Kampala, Uganda.
Praise AtukundaMakerere University Joint AIDS Program, Kampala, Uganda.
Gerald MutungiDepartment of non-communicable diseases, Uganda Ministry of Health, Kampala, Uganda.
Frank MugabeDepartment of non-communicable diseases, Uganda Ministry of Health, Kampala, Uganda.
Fortunate AmbangiraMakerere University Joint AIDS Program, Kampala, Uganda.
Mary MbuliroMakerere University Joint AIDS Program, Kampala, Uganda.
Rodgers KatwesigyeMakerere University Joint AIDS Program, Kampala, Uganda.
Dinesh NeupaneJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Isaac SsinabulyaUganda Initiative for Integrated Management of Non-Communicable Diseases (UINCD), Kampala, Uganda.
Fred Collins SemitalaMakerere University Joint AIDS Program, Kampala, Uganda.
Christian DellesLancet Commission on Hypertension Group, Atlanta, GA, USA.ORCID 0000-0003-2238-2612
Martin MudduMakerere University Joint AIDS Program, Kampala, Uganda.ORCID 0000-0002-4216-0083
Makerere University · UGMinistry of Health · UGJohns Hopkins University · USUganda Management Institute · UGUniversity of Glasgow · GBYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Leveraging existing HIV differentiated service delivery models to screen and treat hypertension in Ugandan persons living with HIV for dual controlK43TW011963 · FIC · INFECTIOUS DISEASES RES COLLABORATION · PI MUDDU, MARTIN · 2021 to 2025
$667k
FIC NIH HHS K43 TW011963NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Multi-month dispensing (MMD) is a patient-centered approach in which stable patients receive medicine refills of three months or more. In this pre-post longitudinal study, we determined hypertension and HIV treatment outcomes in a cohort of hypertensive PLHIV at baseline and 12 months of receiving integrated MMD. At each clinical encounter, one healthcare provider attended to both hypertension and HIV needs of each patient in an HIV clinic. Among the 1,082 patients who received MMD, the mean age was 51 (SD = 9) years and 677 (63%) were female. At the start of MMD, 1,071(98.9%) patients had achieved HIV viral suppression, and 767 (73.5%) had achieved hypertension control. Mean blood pressure reduced from 135/87 (SD = 15.6/15.2) mmHg at the start of MMD to 132/86 (SD = 15.2/10.5) mmHg at 12 months (p < 0.0001). Hypertension control improved from 73.5% to 78.5% (p = 0.01) without a significant difference in the proportion of patients with HIV viral suppression at baseline and at 12 months, 98.9% vs 99.0% (p = 0.65). Patients who received MMD with elevated systolic blood pressure at baseline were less likely to have controlled blood pressure at 12 months (OR-0.9, 95% CI, 0.90,0.92). Overall, 1,043 (96.4%) patients were retained at 12 months. Integrated MMD for stable hypertensive PLHIV improved hypertension control and sustained optimal HIV viral suppression and retention of patients in care. Therefore, it is feasible to provide integrated MMD for both hypertension and HIV treatment and achieve dual control in the setting of sub-Saharan Africa.

Indexed as

Anti-HIV AgentsHIV InfectionsHypertensionAntihypertensive AgentsFemaleHumansLongitudinal StudiesMaleMiddle AgedAnti-HIV AgentsAntihypertensive Agents

Identifiers

PMID35246602
PMCPMC8896410
OpenAlexW4214847095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.