Evidence map›Paper›PMID 35246568›Full record

ArticleScientific reports2022

The genome trilogy of Anopheles stephensi, an urban malaria vector, reveals structure of a locus associated with adaptation to environmental heterogeneity.

Aditi Thakare, Chaitali Ghosh, Tejashwini Alalamath, Naveen Kumar, Himani Narang, Saurabh Whadgar, Kiran Paul, Shweta Shrotri, Sampath Kumar, M Soumya and 7 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

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  7. Phylogeographic Patterns and Genetic Diversity ofTropical medicine and infectious disease · 2025
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  8. The origin, invasion history and resistance architecture ofbioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Aditi Thakare *Institute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronic City Phase I, Bangalore, 560100, India.
Chaitali Ghosh *Tata Institute for Genetics and Society, Center at inStem - GKVK campus, Bellary Road, Bangalore, 560065, India.
Tejashwini Alalamath *Institute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronic City Phase I, Bangalore, 560100, India.
Naveen KumarTata Institute for Genetics and Society, Center at inStem - GKVK campus, Bellary Road, Bangalore, 560065, India.
Himani NarangInstitute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronic City Phase I, Bangalore, 560100, India.
Saurabh WhadgarInstitute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronic City Phase I, Bangalore, 560100, India.
Kiran PaulInstitute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronic City Phase I, Bangalore, 560100, India.
Shweta ShrotriInstitute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronic City Phase I, Bangalore, 560100, India.
Sampath KumarTata Institute for Genetics and Society, Center at inStem - GKVK campus, Bellary Road, Bangalore, 560065, India.
M SoumyaTata Institute for Genetics and Society, Center at inStem - GKVK campus, Bellary Road, Bangalore, 560065, India.
Raksha RaoInstitute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronic City Phase I, Bangalore, 560100, India.
Mahul ChakrabortyUniversity of California, Irvine, CA, 92697, USA.
Bibha ChoudharyInstitute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronic City Phase I, Bangalore, 560100, India.
Susanta K GhoshNational Institute of Malaria Research, Bangalore, 562110, India.
Suresh SubramaniTata Institute for Genetics and Society, Center at inStem - GKVK campus, Bellary Road, Bangalore, 560065, India.
Sunita SwainTata Institute for Genetics and Society, Center at inStem - GKVK campus, Bellary Road, Bangalore, 560065, India. sunita.swain@tigs.res.in.
Subhashini SrinivasanInstitute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronic City Phase I, Bangalore, 560100, India. ssubha@ibab.ac.in.
Institute of Bioinformatics and Applied Biotechnology · INTata Institute for Genetics and Society · INBiotech Park · INInstitute for Stem Cell Biology and Regenerative Medicine · INNational Institute of Malaria Research · INUniversity of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anopheles stephensi is the most menacing malaria vector to watch for in newly urbanising parts of the world. Its fitness is reported to be a direct consequence of the vector adapting to laying eggs in over-head water tanks with street-side water puddles polluted by oil and sewage. Large frequent inversions in the genome of malaria vectors are implicated in adaptation. We report the genome assembly of a strain of An. stephensi of the type-form, collected from a construction site from Chennai (IndCh) in 2016. The genome reported here with a L50 of 4, completes the trilogy of high-resolution genomes of strains with respect to a 16.5 Mbp 2Rb genotype in An. stephensi known to be associated with adaptation to environmental heterogeneity. Unlike the reported genomes of two other strains, STE2 (2R+

Indexed as

AnophelesMalariaAnimalsChromosome InversionIndiaMosquito VectorsWaterWater

Identifiers

PMID35246568
PMCPMC8897464
OpenAlexW4221041490

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.