Evidence map›Paper›PMID 35246558›Full record

ArticleScientific reports2022

Modular polymer platform as a novel approach to head and neck cancer therapy.

Yazeed Alhiyari, Jundong Shao, Albert Y Han, Amanda Miller, Jeffrey F Krane, Marie Luff, Milica Momcilovic, David Shackelford, Zhen Gu, Maie A St John

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. High dose, dual-release polymeric films for extended surgical bed paclitaxel delivery.Journal of controlled release : official journal of the Controlled Release Society · 2023
    Article
  2. Laryngoscope investigative otolaryngology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yazeed Alhiyari *Department of Head and Neck Surgery, David Geffen School of Medicine, University of California, 10833 Le Conte Ave, 62-132 CHS, Los Angeles, CA, 9009, USA.
Jundong Shao *Department of Bioengineering, University of California Los Angeles, Los Angeles, CS, USA.
Albert Y HanDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California, 10833 Le Conte Ave, 62-132 CHS, Los Angeles, CA, 9009, USA.
Amanda MillerDavid Geffen School of Medicine, University of Los Angeles, Los Angeles, CA, USA.
Jeffrey F KraneDepartment of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, CA, USA.
Marie LuffDavid Geffen School of Medicine, University of Los Angeles, Los Angeles, CA, USA.
Milica MomcilovicDGSOM Division of Pulmonary and Critical Care Medicine, Head and Neck Cancer Program, University of Los Angeles, Los Angeles, CA, USA.
David ShackelfordJonsson Comprehensive Cancer Center, University of Los Angeles Medical Center, Los Angeles, CA, USA.
Zhen GuDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CS, USA. ZhenGu@g.ucla.edu.
Maie A St JohnDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California, 10833 Le Conte Ave, 62-132 CHS, Los Angeles, CA, 9009, USA. MStJohn@mednet.ucla.edu.
University of California, Los Angeles · USLos Angeles Medical Center · USUCLA Medical Center · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
NCI NIH HHS P30 CA016042
6 · The paper itself

Abstract

Head and neck cancer is the sixth most common cancer in the world, with more than 300,000 deaths attributed to the disease annually. Aggressive surgical resection often with adjuvant chemoradiation is the cornerstone of treatment. However, the necessary chemoradiation treatment can result in collateral damage to adjacent vital structures causing a profound impact on quality of life. Here, we present a novel polymer of poly(lactic-co-glycolic) acid and polyvinyl alcohol that can serve as a versatile multidrug delivery platform as well as for detection on cross-sectional imaging while functioning as a fiduciary marker for postoperative radiotherapy and radiotherapeutic dosing. In a mouse xenograft model, the dual-layered polymer composed of calcium carbonate/thymoquinone was used for both polymer localization and narrow-field infusion of a natural therapeutic compound. A similar approach can be applied in the treatment of head and neck cancer patients, where immunotherapy and traditional chemotherapy can be delivered simultaneously with independent release kinetics.

Indexed as

Head and Neck NeoplasmsPolymersAnimalsChemoradiotherapy, AdjuvantHumansMiceQuality of LifePolymers

Identifiers

PMID35246558
PMCPMC8897426
OpenAlexW4214893475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.