ArticleNature communications2022
Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Clustered cytoneme interactions contribute to peripheral nervous system patterning in Drosophila.bioRxiv : the preprint server for biology · 2026Article
- Arginine Kinase 1 supports energy homeostasis in Drosophila flight muscle development.PLoS genetics · 2026Article
- Regulation and function of specialized membrane protrusions in intercellular communication.Nature reviews. Molecular cell biology · 2026Review
- Emerging Roles of Cytoneme-Mediated Signaling in Cancer.International journal of molecular sciences · 2026Review
- A flexible repertoire of wound closure strategies precedes whole-body regeneration.Nature communications · 2026Article
- Spatiotemporal control of myoblast identity drives muscle diversity in theScience advances · 2026Article
- Heparan sulfate is essential for Drosophila FGF export.bioRxiv : the preprint server for biology · 2026Article
- Polar cell membrane nanotubes containing microtubules and acidic vesicles render Drosophila eggs fertile.PLoS biology · 2025Article
- FGF diffusion is required for directed migration of postembryonic muscle progenitors in C. elegans.Development (Cambridge, England) · 2025Article
- Cytoneme feedback ensures signaling specificity when multiple ligands converge on a common receptor.bioRxiv : the preprint server for biology · 2025Article
- Ovarian germline stem cell dedifferentiation is cytoneme dependent.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Making cells inter-connected for signaling communication: a developmental view of cytonemes.Cell communication and signaling : CCS · 2025Review
- A collection of split-Gal4 drivers targeting conserved signaling ligands in Drosophila.G3 (Bethesda, Md.) · 2025Article
- The cellular protrusions for inter-cellular material transfer: similarities between filopodia, cytonemes, tunneling nanotubes, viruses, and extracellular vesicles.Frontiers in cell and developmental biology · 2024Review
- Non-Classical Intercellular Communications: Basic Mechanisms and Roles in Biology and Medicine.International journal of molecular sciences · 2023Review
- Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model.Nature communications · 2022Article
- Predictive model for cytoneme guidance in Hedgehog signaling based on Ihog- Glypicans interaction.Nature communications · 2022Article
- GPI-anchored FGF directs cytoneme-mediated bidirectional contacts to regulate its tissue-specific dispersion.Nature communications · 2022Article
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7 authors.
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Abstract
Asymmetric signaling and organization in the stem-cell niche determine stem-cell fates. Here, we investigate the basis of asymmetric signaling and stem-cell organization using the Drosophila wing-disc that creates an adult muscle progenitor (AMP) niche. We show that AMPs extend polarized cytonemes to contact the disc epithelial junctions and adhere themselves to the disc/niche. Niche-adhering cytonemes localize FGF-receptor to selectively adhere to the FGF-producing disc and receive FGFs in a contact-dependent manner. Activation of FGF signaling in AMPs, in turn, reinforces disc-specific cytoneme polarity/adhesion, which maintains their disc-proximal positions. Loss of cytoneme-mediated adhesion promotes AMPs to lose niche occupancy and FGF signaling, occupy a disc-distal position, and acquire morphological hallmarks of differentiation. Niche-specific AMP organization and diversification patterns are determined by localized expression and presentation patterns of two different FGFs in the wing-disc and their polarized target-specific distribution through niche-adhering cytonemes. Thus, cytonemes are essential for asymmetric signaling and niche-specific AMP organization.
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