Evidence map›Paper›PMID 35246528›Full record

ArticleNature communications2022

Neuronal activity in sensory cortex predicts the specificity of learning in mice.

Katherine C Wood, Christopher F Angeloni, Karmi Oxman, Claudia Clopath, Maria N Geffen

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Distinct Inhibitory Neurons Differently Shape Neuronal Codes for Sound Intensity in the Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Katherine C WoodDepartments of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-5520-5025
Christopher F AngeloniDepartments of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Karmi OxmanDepartments of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Claudia ClopathDepartment of Bioengineering, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-4507-8648
Maria N GeffenDepartments of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA. mgeffen@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0003-3022-2993
University of Pennsylvania · USImperial College London · GBPenn Center for AIDS Research · US

Funding

Circuit Mechanisms of Sound Processing and Detection in the Auditory PathwayR01DC014479 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI GEFFEN, MARIA NEIMARK · 2015 to 2024
$4.7M
Neuronal circuits supporting learning-driven changes in auditory perception.R01DC015527 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI Maria Neimark Geffen · 2017 to 2026
$4.5M
Neuronal circuits for context-driven bias in auditory categorizationR01NS113241 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI COHEN, YALE E, GEFFEN, MARIA NEIMARK · 2019 to 2023
$3.5M
NIDCD NIH HHS R01 DC014479NIDCD NIH HHS R01 DC015527NINDS NIH HHS R01 NS113241
6 · The paper itself

Abstract

Learning to avoid dangerous signals while preserving normal responses to safe stimuli is essential for everyday behavior and survival. Following identical experiences, subjects exhibit fear specificity ranging from high (specializing fear to only the dangerous stimulus) to low (generalizing fear to safe stimuli), yet the neuronal basis of fear specificity remains unknown. Here, we identified the neuronal code that underlies inter-subject variability in fear specificity using longitudinal imaging of neuronal activity before and after differential fear conditioning in the auditory cortex of mice. Neuronal activity prior to, but not after learning predicted the level of specificity following fear conditioning across subjects. Stimulus representation in auditory cortex was reorganized following conditioning. However, the reorganized neuronal activity did not relate to the specificity of learning. These results present a novel neuronal code that determines individual patterns in learning.

Indexed as

Auditory CortexConditioning, ClassicalAnimalsFearHumansLearningMiceNeurons

Identifiers

PMID35246528
PMCPMC8897443
OpenAlexW4214881875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.