ArticleBiological psychiatry2022
Convergent Coding of Recent and Remote Fear Memory in the Basolateral Amygdala.
Article in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 44 citations in OpenAlex.
- Threat Conditioning Prior to Cocaine or Sucrose Exposure Alters Reward-Seeking Behavior in a Sex-Dependent Manner.Psychiatry international · 2026Article
- A Non-Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Primary auditory cortex activity during early retrieval supports later extinction learning.Neurobiology of learning and memory · 2025Article
- Functional synaptic connectivity of engrafted spinal cord neurons with hindlimb motor circuitry in the injured spinal cord.Nature communications · 2025Article
- Integrating Aversive Memories in the Basolateral Amygdala.Biological psychiatry · 2025Review
- Basolateral Amygdala Memory in the Fourth Dimension.Biological psychiatry · 2025Article
- A coordinated and enhanced brain network supports the persistence of long-term cocaine memory.Translational psychiatry · 2025Article
- How Fear Memory is Updated: From Reconsolidation to Extinction?Neuroscience bulletin · 2025Review
- Auditory fear memory retrieval requires BLA-LS and LS-VMH circuitries via GABAergic and dopaminergic neurons.EMBO reports · 2025Article
- Article
- Combined loss of brevican, neurocan, tenascin-C and tenascin-R leads to impaired fear retrieval due to perineuronal net loss.Scientific reports · 2025Article
- Exploring the therapeutic potential of psychedelics: Fear extinction mechanisms and amygdala modulation.Psychedelics · 2025Article
- Progress in spatiotemporal regulation of fear memory: neural circuit mechanisms and implications for PTSD.General psychiatry · 2025Review
- Multi-regional control of amygdalar dynamics reliably reflects fear memory age.Nature communications · 2024Article
- Ventral Pallidum Neurons Are Necessary to Generalize and Express Fear-Related Responding in a Minimal Threat Setting.eNeuro · 2024Article
- Behavioral outputs and overlapping circuits between conditional fear and active avoidance.Neurobiology of learning and memory · 2024Review
- Neurobiology of Stress-Induced Nicotine Relapse.International journal of molecular sciences · 2024Review
- Neurotoxic lesions of the anterior claustrum influence cued fear memory in rats.Frontiers in psychiatry · 2024Article
- Elevated fear states facilitate ventral hippocampal engagement of basolateral amygdala neuronal activity.Frontiers in behavioral neuroscience · 2024Article
- Pavlovian Fear Conditioning Is More than You Think It Is.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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5 authors at 1 institution in 1 country.
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Abstract
backgroundIn both rodents and humans, the basolateral amygdala (BLA) is essential for encoding and retrieving conditioned fear memories. Although the BLA is a putative storage site for these memories, recent evidence suggests that they become independent of the BLA with the passage of time.
methodsWe systematically examined the role for the BLA in the retrieval of recent (1 day) and remote (2 weeks) fear memory using optogenetic, electrophysiological, and calcium imaging methods in male and female Long-Evans rats. Critically, we used a behavioral design that permits within-subjects comparison of recent and remote memory at the same time point; freezing behavior served as the index of learned fear.
resultsWe found that BLA c-Fos expression was similar after the retrieval of recent or remote fear memories. Extracellular single-unit recordings in awake, behaving animals revealed that single BLA neurons exhibit robust increases in spike firing to both recent and remote conditioned stimuli. Fiber photometry recordings revealed that these patterns of activity emerge from principal neurons. Consistent with these results, optogenetic inhibition of BLA principal neurons impaired conditioned freezing to both recent and remote conditioned stimuli. There were no sex differences in any of the measures or manipulations.
conclusionsThese data reveal that BLA neurons encode both recent and remote fear memories, suggesting substantial overlap in the allocation of temporally distinct events. This may underlie the broad generalization of fear memories across both space and time. Ultimately, these results provide evidence that the BLA is a long-term storage site for emotional memories.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.