ArticleVirology journal2022
Prevalence and distribution of human papillomavirus (HPV) in Luoyang city of Henan province during 2015-2021 and the genetic variability of HPV16 and 52.
Article in Virology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Distribution of HPV types among women with HPV-related diseases and exploration of lineages and variants of HPV 52 and 58 among HPV-infected patients in China: A systematic literature review.Human vaccines & immunotherapeutics · 2024Pooled it
- Clinical epidemiology and associations between HPV infection and vaginal infections in Jinan, China: a cross-sectional analysis.Frontiers in cellular and infection microbiology · 2026Article
- Prevalence and genotype distribution of HPV infection among women in Chengdu from 2019 to 2024: a retrospective single-center study.Infectious agents and cancer · 2025Article
- HPV prevalence and genotype distribution among women in sanming, China: a retrospective analysis before large-scale vaccination.Infectious agents and cancer · 2025Article
- Epidemiological characteristics and genotype distribution of human papillomavirus infection in Yangpu district, Shanghai, 2020-2024.Virology journal · 2025Article
- Article
- Detection of Multiple Human Viruses, including Mpox, Using a Wastewater Surveillance Approach in Brazil.Pathogens (Basel, Switzerland) · 2024Article
- Epidemiology and genotypes analysis of human papillomavirus infection in Huizhou, China.Frontiers in public health · 2024Article
- HPV prevalence and genotype distribution among women in eastern China during the Covid-19 pandemic.Human vaccines & immunotherapeutics · 2023Article
- Prevalence and risk factors of oral human papillomavirus infection among 4212 healthy adults in Hebei, China.BMC infectious diseases · 2023Article
- Distribution of Human Papillomavirus Genotypes among the Women of South Andaman Island, India.Diagnostics (Basel, Switzerland) · 2023Article
- Development of a simplified and cost-effective sample preparation method for genotyping of human papillomavirus by next-generation sequencing.Archives of virology · 2023Article
- Article
- Prevalence and genotype distribution of human papillomavirus infections in Beijing, China between 2016 and 2020.Virology journal · 2023Article
- Genetic variability in the E6 and E7 oncogenes of HPV52 and its prevalence in the Taizhou area, China.Virology journal · 2022Article
- Challenges and Needs of HPV-Positive Women.Inquiry : a journal of medical care organization, provision and financingArticle
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6 authors.
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Abstract
backgroundPersistent high-risk Human papillomavirus (HPV) subtypes infection has been implicated as a causative of cervical cancer. Distribution and genotypes of HPV infection among females and their variations would assist in the formulation of preventive strategy for cervical cancer. The purpose of the present study is to investigate the prevalence of HPV among females in central China.
methodsThe distribution and genotypes of HPV among 9943 females attending the gynecological examinations in central of China during 2015-2021 were investigated. HPV genotypes were detected using a commercial kit. Nucleotides sequences of L1, E6 and E7 genes in HPV16 or HPV52 positive samples collected in 2021 were amplified by polymerase chain reaction (PCR). Variations of L1, E6 and E7 in HPV16 and HPV52 were gained by sequencing and compared with the reference sequence. Sublineages of HPV16 and HPV52 were determined by the construction of phylogenetic tree based on L1 gene.
resultsThe overall prevalence of HPV infection was 22.81%, with the infection rate of high-risk human papillomavirus (HR-HPV) was 19.02% and low-risk human papillomavirus (LR-HPV) was 6.40%. The most top five genotypes of HPV infection were HPV16 (7.49%), HPV52 (3.04%), HPV58 (2.36%), HPV18 (1.65%) and HPV51 (1.61%). Plots of the age-infection rate showed that the single HPV, multiple HPV, HR-HPV, LR-HPV infection revealed the same tendency with two peaks of HPV infection were observed among females aged ≤ 20 year-old and 60-65 year-old. The predominant sublineage of HPV16 was A1 and B2 for HPV52. For HPV16, The most prevalent mutations were T266A (27/27) and N181T (7/27) for L1, D32E for E6 and S63F for E7 in HPV16. For HPV52, all of the nucleotide changes were synonymous mutation in L1 (except L5S) and E7 genes. The K93R mutation was observed in most HPV52 E6 protein.
conclusionsThe present study provides basic information about the distribution, genotypes and variations of HPV among females population in Henan province, which would assist in the formulation of preventive strategies and improvements of diagnostic probe and vaccine for HPV in this region.
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